1. Immunology/Inflammation
    Metabolic Enzyme/Protease
    Neuronal Signaling
    Stem Cell/Wnt
    NF-κB
    Anti-infection
  2. COX
    Lipoxygenase
    Notch
    Reactive Oxygen Species
    Bacterial
  3. Psoralidin

Psoralidin 

Cat. No.: HY-N0232 Purity: 99.90%
Handling Instructions

Psoralidin, isolated from the seed of Psoralea corylifolia, is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.

For research use only. We do not sell to patients.

Psoralidin Chemical Structure

Psoralidin Chemical Structure

CAS No. : 18642-23-4

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5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Description

Psoralidin, isolated from the seed of Psoralea corylifolia, is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties[1]. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation[2].

IC50 & Target[1]

COX-2

 

5-LOX

 

In Vitro

Three breast cancer cell (BCC)populations (ALDH- cells, ALDH+ cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC50s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin[2].
Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH- cells, ALDH+ cells, and commercial BCSCs[2].
Psoralidin treatment also downregulates NOTCH1 expression in both ALDH- and ALDH+ cells[2].

Cell Viability Assay[2]

Cell Line: ALDH- cells, ALDH+ cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A)
Concentration: 10, 15, 50, and 25 μM
Incubation Time: 24 hours
Result: IC50s of 18 to 21 μM for ALDH- cells, ALDH+ cells, commercial BCSCs.

Apoptosis Analysis[2]

Cell Line: ALDH- cells, ALDH+ cells, and commercial BCSCs
Concentration: 20 and 30 μM
Incubation Time: 24 hours
Result: No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH- cells, ALDH+ cells, and commercial BCSCs, respectively.
In Vivo

Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse[1].

Animal Model: BALB/c mice[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy).
Result: Anti-inflammatory effect in IR-irradiated mice.
Molecular Weight

336.34

Formula

C₂₀H₁₆O₅

CAS No.

18642-23-4

SMILES

O=C1C2=C(OC3=CC(O)=CC=C32)C4=CC(C/C=C(C)\C)=C(O)C=C4O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

PsoralidinCOXLipoxygenaseNotchReactive Oxygen SpeciesBacterialCyclooxygenaseLOXIonizingradiationIRCOX-25-LOXAnti-inflammationNOTCH1reactiveoxygenspeciesROSInhibitorinhibitorinhibit

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