Osteostatin (human)
Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis.
For research use only. We do not sell to patients.
- CAS No.: 137348-10-8
- Formula: C142H228N42O58
- Molecular Weight:3451.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Osteostatin (100, 250 and 500 nM) decreases the differentiation of osteoclasts in a concentration-dependent manner, but it does not modify the resorptive ability of mature osteoclasts. In addition, Osteostatin decreases the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1[1].
Osteostatin (human) potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cell cultures[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 137348-10-8
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Molecular Weight 3451.58
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Formula C142H228N42O58
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Synonyms
Human PTHrP(107-139)
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Sequence
Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg
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Sequence Shortening
TRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [Content Brief]
[2]. C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Osteostatin (human) Related Classifications
HY-P4800 Related Classifications
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