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Capillarisin 

Cat. No.: HY-121192
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Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity.

For research use only. We do not sell to patients.

Capillarisin Chemical Structure

Capillarisin Chemical Structure

CAS No. : 56365-38-9

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Description

Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].

In Vitro

Capillarisin (0~40 μM; 24 hours; SH-SY5Y cells) does not produce any significant changes on the viability of SH-SY5Y cells[3].
. Capillarisin (40 μM; 24 hours; SH-SY5Y cells) induces PI3K/PKB pathway inactivation, which inhibiting apoptosis in bupivacaine-challenged SH-SY5Y cells is overturned by LY294002 treatment and counteracts bupivacaine-induced injury via activating the PI3K/PKB pathway[3].
. Capillarisin antagonizes bupivacaine-induced oxidative stress via activating the PI3K/PKB pathway in SH-SY5Y cells. Capillarisin inhibits bupivacaine-induced mitochondrial injury and endoplasmic reticulum stress via activating PI3K/PKB pathway[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 0~40 μM
Incubation Time: 24 hours
Result: Did not produce any significant changes on the viability of SH-SY5Y cells.

Western Blot Analysis[3]

Cell Line: SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 hours
Result: Induced PI3K/PKB pathway inactivation in SH-SY5Y cells.

Apoptosis Analysis[3]

Cell Line: SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 hours
Result: Induced inhibition of apoptosis in bupivacaine-challenged SH-SY5Y cells was overturned by LY294002 treatment.
In Vivo

Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[4]
Dosage: 20 and 80 mg/kg
Administration: I.p.; 1 hour
Result: Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).
Molecular Weight

316.26

Formula

C₁₆H₁₂O₇

CAS No.
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Storage

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Capillarisin
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