Tulisokibart
Based on 1 publication(s) in Google Scholar
Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis.
For research use only. We do not sell to patients.
- Purity : 98.69%
- CAS No.: 2648504-55-4
- Molecular Weight:143.96 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Tulisokibart
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Biological Activity
Description
Isotype
Human IgG1 (L234A/L235A) kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
TNFSF15
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Tulisokibart (HY-P990007). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Immobilized TL1A/TNFSF15 Protein, Human can bind Tulisokibart. The EC50 for this effect is 15.31 ng/mL. -
Loaded Tulisokibart on AHC2 biosensor, can bind TL1A/TNFSF15 Protein, Human (HY-P71913) with an affinity constant of 3.693E-10 M as determined in BLI assay.
Chemical Information
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CAS No. 2648504-55-4
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Appearance Liquid
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Molecular Weight 143.96 kDa
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Color Colorless to light yellow
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SMILES
[Tulisokibart]
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Synonyms
PRA023; MK-7240
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Inflamm Bowel Dis
Preclinical development of SL-325, a novel high-affinity DR3-blocking antibody for durable inhibition of the DR3/TL1A axis in inflammatory bowel disease. [Abstract]2026 Jun 27:izag101. PMID: 42364076
Purity & Documentation
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Data Sheet (261 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)