TNFSF15 - TNF superfamily member 15 Gene

Homo sapiens

Also known as TL1; TL1A; VEGI; TNLG1B; VEGI192A

Gene ID: 9966 | Gene type: protein coding

About TNFSF15

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,784,635-114,806,039 (from NCBI)

This gene has 2 transcripts (splice variants), 122 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce Apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TNFSF15 Products(2)

mRNA	Protein	Name
NM_001204344.1	NP_001191273.1	tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
NM_005118.4	NP_005109.2	tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor

TNFSF15 Protein Structure

TNF

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 15

TNF ligand-related molecule 1

Recombinant TNFSF15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71913	TL1A/TNFSF15 Protein, Human	O95150 (L72-L251)	≥95%
HY-P71981	TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His)	O95150-2 (M1-L192)	≥95%
HY-P78447	TL1A/TNFSF15 Trimer Protein, Human (HEK293, His-Flag)	O95150-1 (D91-L251)	≥95%
HY-P700153AF	Animal-Free TL1A/TNFSF15 Protein, Human (His)	O95150 (Q58-L251)	≥95%
HY-P701048	TL1A/TNFSF15 Protein, Human (180a.a, HEK293, His)	O95150-1 (L72-L251)	≥95%

Related Diseases

Diseases

Alias

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diverticulitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease 15

IBD15

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Inflammatory Bowel Disease 5

IBD5

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Inflammatory Bowel Disease 19

Inflammatory Bowel Disease 19	IBD19
Bowel Disease, Inflammatory, Type 19

Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Ileitis

Crohn'S Ileitis

Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2	Temporal Epilepsy, Familial
ETL2	Ftle
Epilepsy, Familial Temporal Lobe	Familial Temporal Lobe Epilepsy

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990007	Tulisokibart	Inhibitor	95.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14826	TNFSF15 Human Pre-designed siRNA Set A		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990006	Duvakitug	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF15	VGNC	VGNC:36174
Canis familiaris	TNFSF15	VGNC	VGNC:47671
Rattus norvegicus	TNFSF15	RGD	RGD:628735
Mus musculus	TNFSF15	MGD	MGI:2180140
Macaca mulatta	TNFSF15	VGNC	VGNC:78596
Felis catus	TNFSF15	VGNC	VGNC:66415
Macaca fascicularis	TNFSF15	NCBI
Others	TNFSF15	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.