TNFSF15 Antibody
(Synonyms: TL1, VEGI, TNFSF15, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor)TNFSF15 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNFSF15.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, mIHC
-
Reactivity :
Human, Mouse
-
Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
mIHC
mIHC: Multiplex Immunohistochemical
|
|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:500 |
Product Details
TNFSF15 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNFSF15.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse Predicted Reactivity: Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
-
Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 28 kDa
KLH conjugated synthetic peptide derived from human TNFSF15 Extracellular : 150-251/251.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
TNFSF15 is a cytokine that transmits signals through the TNFRSF25 receptor. As a T-cell co-stimulatory molecule, it enhances IL-2 responsiveness and the secretion of pro-inflammatory cytokines, thereby promoting T-cell activation, proliferation, and survival of activated T cells. TNFSF15 inhibits vascular endothelial cell growth and angiogenesis. TNFSF15 binds to the decoy receptor TNFRSF6B, blocking activation that is normally triggered by TNFSF15, thereby reducing T cell activation and alleviating inflammation.
-
Subcellular Localization
Membrane; Single-pass type II membrane protein
-
Expression
Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF. -
Isoforms & Post-Translational Modification
TNFSF15 has three isomers: TL1A; 28,087 Da (predicted); VEGI-192; 21,857 Da (predicted); VEGI-174; 20,131 Da (predicted).
-
Subunit
Homotrimer. TNFSF15 binds TNFRSF6B with 3:3 stoichiometry.
-
SwissProt ID
-
Synonyms
TL1, VEGI, TNFSF15, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor
Documentation
Powered by Bioz
