1. Saccharides and Glycosides
    Terpenoids and Glycosides
  2. Oxypaeoniflorin

Oxypaeoniflorin 

Cat. No.: HY-N0748 Purity: 98.06%
Handling Instructions

Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects.

For research use only. We do not sell to patients.

Oxypaeoniflorin Chemical Structure

Oxypaeoniflorin Chemical Structure

CAS No. : 39011-91-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 218 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 218 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 198 In-stock
Estimated Time of Arrival: December 31
10 mg USD 346 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Oxypaeoniflorin purchased from MCE. Usage Cited in: J Food Nutr Res. 2018, 6(1), 26-31.

    LPS-induced RAW264.7 cells are pre-treated with the MCR extract (50 and 100 μg/mL), Paeoniflorin (10 and 30 μM), and Oxypaeoniflorin (10 and 30 μM) for 4 h and then co-treated with LPS (1 μg/ml) for 18 h. The expression of iNOS protein using western blot.
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    Description

    Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects[1][2].

    In Vitro

    Oxypaeoniflorin (OPA; 0.1-10 µM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells[1].
    Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury[1]
    Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg
    Administration: Intragastrical administration; every day; for 30 days
    Result: Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS).
    Molecular Weight

    496.46

    Formula

    C₂₃H₂₈O₁₂

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (201.43 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0143 mL 10.0713 mL 20.1426 mL
    5 mM 0.4029 mL 2.0143 mL 4.0285 mL
    10 mM 0.2014 mL 1.0071 mL 2.0143 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    Oxypaeoniflorin
    Cat. No.:
    HY-N0748
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