2. Natural Products
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  4. Paeoniaceae
    Other Monoterpenes
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  5. Paeonia lactiflora Pall.
  6. Oxypaeoniflorin

Oxypaeoniflorin 

Cat. No.: HY-N0748 Purity: 98.37%
COA Handling Instructions

Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects.

For research use only. We do not sell to patients.

Oxypaeoniflorin Chemical Structure

Oxypaeoniflorin Chemical Structure

CAS No. : 39011-91-1

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Solution
10 mM * 1 mL in DMSO USD 218 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 218 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 198 In-stock
Estimated Time of Arrival: December 31
10 mg USD 346 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Oxypaeoniflorin purchased from MCE. Usage Cited in: J Food Nutr Res. 2018, 6(1), 26-31.

    LPS-induced RAW264.7 cells are pre-treated with the MCR extract (50 and 100 μg/mL), Paeoniflorin (10 and 30 μM), and Oxypaeoniflorin (10 and 30 μM) for 4 h and then co-treated with LPS (1 μg/ml) for 18 h. The expression of iNOS protein using western blot.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects[1][2].

    In Vitro

    Oxypaeoniflorin (OPA; 0.1-10 µM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells[1].
    Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    In Vivo

    Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury[1]
    Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg
    Administration: Intragastrical administration; every day; for 30 days
    Result: Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS).
    Molecular Weight

    496.46

    Appearance

    Solid

    Formula

    C23H28O12
    CAS No.
    SMILES
    Structure Classification
    Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (201.43 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0143 mL 10.0713 mL 20.1426 mL
    5 mM 0.4029 mL 2.0143 mL 4.0285 mL
    10 mM 0.2014 mL 1.0071 mL 2.0143 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 98.37%

    COA (259 KB) HNMR (302 KB) RP-HPLC (245 KB) MS (208 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Oxypaeoniflorin39011-91-1OthersSirt1Foxo1monoterpeneglycosideCK-MBneuroprotectiveanti-inflammatoryanti-oxidantInhibitorinhibitorinhibit

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