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POM1 (Synonyms: Sodium polyoxotungstate; Sodium metatungstate)

Cat. No.: HY-103259
Handling Instructions

POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.

For research use only. We do not sell to patients.

POM1 Chemical Structure

POM1 Chemical Structure

CAS No. : 12141-67-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].

IC50 & Target

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (16.74 mM; Need ultrasonic)

DMSO : 50 mg/mL (16.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3349 mL 1.6745 mL 3.3490 mL
5 mM 0.0670 mL 0.3349 mL 0.6698 mL
10 mM 0.0335 mL 0.1674 mL 0.3349 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

2986.01

Formula

H₂Na₆O₄₀W₁₂

CAS No.

12141-67-2

SMILES

O=[W+4]([O-2]1)([O-2]2)([O-2]3)([O-2]4)[OH-]5[W+4]1([O-2][W+4]([OH-]6[W+4]7([O-2][W+4]528([O-2][W+4]9([O-2]%10[W+4]3%11([O-2][W+4]4([O-2]%12[W+4]%13%14%15([O-2][W+4]%12%16([O-2][W+4]6%17%18([O-2][W+4]%10%19%20%21=O)=O)([O-2]%21)=O)=O)([O-2]%14)([O-2]%16)=O)([O-2]%19)=O)([O-2]%20)([O-2]%11)=O)=O)([O-2]%18)([O-2]9)=O)([O-2]%15)([O-2]%17)([O-2]7)=O)([O-2]8)([O-2]%13)=O.[6Na+]

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
POM1
Cat. No.:
HY-103259
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POM1

Cat. No.: HY-103259