Sodium metatungstate (Synonyms: Sodium polyoxotungstate; POM-1)

Name: Sodium metatungstate
Brand: MedChemExpress
SKU: HY-103259
Rating: 5.0 (11 reviews)

Cat. No.: HY-103259 Assay: 93.4%: Data Sheet
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SDS
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Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission.

For research use only. We do not sell to patients.

CAS No. : 12141-67-2

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 11 publication(s) in Google Scholar

11 Publications Citing Use of MCE Sodium metatungstate

Bio/Physico-chemical Assay

Flow Cytometry

: Sodium metatungstate purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Jan 27:20:1083-1100. [Abstract]; ApoEVs hydrolyze ATP dose-dependently, which can be significantly mitigated by Sodium metatungstate (POM-1, 100 μM).

: Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364. [Abstract]; FTIR spectra of Fe-PDAP, ICG, Sodium metatungstate (POM-1) and FIP.

: Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364. [Abstract]; The photothermal effect of FIP on cancer cells was assessed by flow cytometry. As expected, both FI and FIP displayed obvious cytotoxic toward 4T1 cells when subjected to 808 nm laser irradiation (1.5 W/cm^-2, 10 min), suggesting that ICG is responsible for the photothermal killing effect rather than Sodium metatungstate (POM-1).

: Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364. [Abstract]; The Ade level of the FI + Laser group was significantly higher than the control group and FIP + Laser group at 6 h after laser irradiation, indicating the PTT could enhance the Ade generation and Sodium metatungstate (POM-1) could inhibit the Ade generation.

: Sodium metatungstate purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 Nov 21:13:1026994.; CD3/CD28-stimulated VPD-stained CD4+ T cells were co-cultured with Treg clones (ratio 1:1) in the presence or not of CD39 and CD73 inhibitors, namely Sodium metatungstate (POM-1, 30 μM) and AB-680 (100 nM), respectively, as indicated. Proliferation was evaluated by VPD dilution.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively^[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission^[1]^[2]^[3]^[4].

IC₅₀ & Target

IL-1β

P2X7 Receptor

In Vitro

Sodium metatungstate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage^[2].
Sodium metatungstate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage^[2].
Sodium metatungstate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium metatungstate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice^[3].
Sodium metatungstate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells^[4]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.

Molecular Weight

2986.01

Formula

H₂Na₆O₄₀W₁₂

CAS No.

12141-67-2

Appearance

Solid

Color

White to off-white

SMILES

[3Na2WO4.9WO3]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (16.74 mM; Need ultrasonic)

DMSO : 50 mg/mL (16.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3349 mL	1.6745 mL	3.3490 mL
5 mM	0.0670 mL	0.3349 mL	0.6698 mL
10 mM	0.0335 mL	0.1674 mL	0.3349 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (33.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 93.4%

Select Batch:

Data Sheet (277 KB) SDS (476 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Wall M J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition [J]. Neuropharmacology, 2008, 55(7): 1251-1258. [Content Brief]

[2]. Pimenta-dos-Reis G, et al. POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages [J]. Purinergic Signalling, 2017, 13: 611-627. [Content Brief]

[3]. Csóka B, et al. CD39 improves survival in microbial sepsis by attenuating systemic inflammation [J]. The FASEB Journal, 2015, 29(1): 25. [Content Brief]

[4]. Yang R, et al. Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade [J]. Journal for immunotherapy of cancer, 2020, 8(1). [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.3349 mL	1.6745 mL	3.3490 mL	8.3724 mL
	5 mM	0.0670 mL	0.3349 mL	0.6698 mL	1.6745 mL
	10 mM	0.0335 mL	0.1674 mL	0.3349 mL	0.8372 mL
	15 mM	0.0223 mL	0.1116 mL	0.2233 mL	0.5582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium metatungstate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sodium metatungstate (Synonyms: Sodium polyoxotungstate; POM-1)

Customer Review

Sodium metatungstate Related Antibodies

11 Publications Citing Use of MCE Sodium metatungstate

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Biological Activity

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References

Customer Review

Sodium metatungstate Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

Sodium metatungstate Related Classifications

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