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Sodium metatungstate (Synonyms: Sodium polyoxotungstate; POM-1)

Cat. No.: HY-103259
Handling Instructions

Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.

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Sodium metatungstate Chemical Structure

Sodium metatungstate Chemical Structure

CAS No. : 12141-67-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].

IC50 & Target

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].

Molecular Weight

2986.01

Formula

H₂Na₆O₄₀W₁₂

CAS No.

12141-67-2

SMILES

O=[W+4]([O-2]1)([O-2]2)([O-2]3)([O-2]4)[OH-]5[W+4]1([O-2][W+4]([OH-]6[W+4]7([O-2][W+4]528([O-2][W+4]9([O-2]%10[W+4]3%11([O-2][W+4]4([O-2]%12[W+4]%13%14%15([O-2][W+4]%12%16([O-2][W+4]6%17%18([O-2][W+4]%10%19%20%21=O)=O)([O-2]%21)=O)=O)([O-2]%14)([O-2]%16)=O)([O-2]%19)=O)([O-2]%20)([O-2]%11)=O)=O)([O-2]%18)([O-2]9)=O)([O-2]%15)([O-2]%17)([O-2]7)=O)([O-2]8)([O-2]%13)=O.[6Na+]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (16.74 mM; Need ultrasonic)

DMSO : 50 mg/mL (16.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3349 mL 1.6745 mL 3.3490 mL
5 mM 0.0670 mL 0.3349 mL 0.6698 mL
10 mM 0.0335 mL 0.1674 mL 0.3349 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Sodium metatungstate
Cat. No.:
HY-103259
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