2. GPCR/G Protein
  3. Adenosine Receptor
  4. Imaradenant

Imaradenant  (Synonyms: HTL1071; AZD4635)

Cat. No.: HY-101980 Purity: 99.55%
COA Handling Instructions

AZD4635 (HTL1071) est un récepteur de l'adénosine A2A (A2AR) qui est puissant, sélectif et oralement actif. AZD4635 se lie à l'A2AR humain avec un Ki de 1,7 nM et présente une sélectivité >30 fois supérieure à celle des autres récepteurs de l'adénosine.

AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors.

For research use only. We do not sell to patients.

Imaradenant Chemical Structure

Imaradenant Chemical Structure

CAS No. : 1321514-06-0

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Solution
10 mM * 1 mL in DMSO USD 99 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Imaradenant Related Antibodies

Top Publications Citing Use of Products

View All Adenosine Receptor Isoform Specific Products:

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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  • Customer Review

Description

AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors[1].

IC50 & Target

Ki: 1.7 nM (A2AR)[1]
In Vitro

In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Imaradenant Related Antibodies
Clinical Trial
Molecular Weight

315.73

Appearance

Solid

Formula

C15H11ClFN5
CAS No.
SMILES

NC1=NC(C2=CC=C(F)C=C2)=C(C3=CC(Cl)=NC(C)=C3)N=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (263.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1673 mL 15.8363 mL 31.6726 mL
5 mM 0.6335 mL 3.1673 mL 6.3345 mL
10 mM 0.3167 mL 1.5836 mL 3.1673 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.68%

COA (251 KB) HNMR (212 KB) LCMS (137 KB)

Handling Instructions (2659 KB)
References
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Imaradenant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Imaradenant1321514-06-0HTL1071 AZD4635HTL 1071HTL-1071AZD4635AZD 4635AZD-4635Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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