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  4. Anti-inflammatory agent 19

Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.

For research use only. We do not sell to patients.

Anti-inflammatory agent 19

Anti-inflammatory agent 19 Chemical Structure

CAS No. : 2873386-63-9

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Anti-inflammatory agent 19 Related Antibodies

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Description

Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc[1].

IC50 & Target

IC50: 36.00 μM (NO)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
36 μM
Compound: 2b
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 34800877]
Molecular Weight

522.71

Formula

C30H50O7
CAS No.
SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@@](C)([C@H]([C@H]4O)O)CO)C)C)([H])[C@](C)([C@](CC1)([H])[C@](C)(O)CO)CCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 192873386-63-9NO SynthaseNitric oxide synthasesNOSRAW 264.7 cellsPentacyclic triterpenesPTsBiotransformationHigh mobility group box-1 proteinHMGB1Anti-inflammatory activityStreptomyces olivaceus CICC 236283,4-seco-triterpenesCOVID-19sepsisInhibitorinhibitorinhibit

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Anti-inflammatory agent 19
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