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Leupeptin

61 Cited Publications
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Based on 61 publication(s) in Google Scholar

Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.

For research use only. We do not sell to patients.

  • CAS No.: 55123-66-5
  • Formula: C20H38N6O4
  • Molecular Weight:426.55
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Leupeptin Chemical Structure
    Leupeptin Chemical Structure
  • Experimental Validation Results for Leupeptin
  • Experimental Validation Results for Leupeptin
  • Experimental Validation Results for Leupeptin
  • Experimental Validation Results for Leupeptin
  • Experimental Validation Results for Leupeptin
CAS No.: 55123-66-5
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  • Leupeptin Chemical Structure
    Leupeptin Chemical Structure
    1/16
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    Leupeptin purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2024 Sep 2;17(1):78. [Abstract]

    Customer Validation
     The LTF expression was detected under MG132 (10 μM) or Leupeptin (100 μM) treatment.

  • 1/16

    Leupeptin purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Feb;21(2):352-373. [Abstract]

    Customer Validation
     Immunoblotting showing the level of PLCG1 in NPC after treatment with Leu (10 μM), NH4Cl (20 mM), or their combination for 12 h. Right panels represent normalized (/NC) band intensities of interest.

  • 1/16

    Leupeptin purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Feb;21(2):352-373. [Abstract]

    Customer Validation
     Western blot showing PLCG1 levels in NPC treated with a combination of Leu (10 μM) and NH4Cl (N/L) for 3, 6, and 9 h. Right panels represent normalized (/NC) band intensities of interest.

  • 1/16

    Leupeptin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Jan;30(1):137-151. [Abstract]

    Customer Validation
     Western blot analysis of SLC7A11, SOCS2 and tubulin proteins in SK-Hep-1 and HepG2 cells at 4 h after 4 Gy IR. Leupeptin (50 μM) were added before IR.

  • 1/16

    Leupeptin purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Aug;17(8):1873-1888. [Abstract]

    Customer Validation
     661 W cells were transfected with the indicated siRNA for 24 h. Then, 661 W cells were treated with 10 μg/ml Leupeptin for 24 h. Cell lysates were collected for western blot analysis of LC3B and GAPDH.

  • Leupeptin