1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Triamcinolone

Triamcinolone 

Cat. No.: HY-B0328 Purity: 99.15%
Handling Instructions

Triamcinolone is a long-acting synthetic corticosteroid.

For research use only. We do not sell to patients.

Triamcinolone Chemical Structure

Triamcinolone Chemical Structure

CAS No. : 124-94-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 180 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Triamcinolone is a long-acting synthetic corticosteroid. Triamcinolone is a corticosteroid hormone receptor agonist and an anti-inflammatory agent. Target: Glucocorticoid Receptor Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress [1]. The mean duration of follow-up was 40 months. The rate of decline in the FEV1 after bronchodilator use was similar in the 559 participants in the triamcinolone group and the 557 participants in the placebo group (44.2+/-2.9 vs. 47.0+/-3.0 ml per year, P= 0.50). Members of the triamcinolone group had fewer respiratory symptoms during the course of the study (21.1 per 100 person-years vs. 28.2 per 100 person-years, P=0.005) and had fewer visits to a physician because of a respiratory illness (1.2 per 100 person-years vs. 2.1 per 100 person-years, P=0.03). Those taking triamcinolone also had lower airway reactivity in response to methacholine challenge at 9 months and 33 months (P=0.02 for both comparisons) [2].

Clinical Trial
Molecular Weight

394.43

Formula

C₂₁H₂₇FO₆

CAS No.

124-94-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (253.53 mM; Need ultrasonic)

H2O : 1 mg/mL (2.54 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5353 mL 12.6765 mL 25.3530 mL
5 mM 0.5071 mL 2.5353 mL 5.0706 mL
10 mM 0.2535 mL 1.2677 mL 2.5353 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TriamcinoloneGlucocorticoid ReceptorInhibitorinhibitorinhibit

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Triamcinolone
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HY-B0328
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