2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Sarecycline hydrochloride

Sarecycline hydrochloride  (Synonyms: P-005672 hydrochloride)

Cat. No.: HY-13858A Purity: 98.01%
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Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .

For research use only. We do not sell to patients.

Sarecycline hydrochloride Chemical Structure

Sarecycline hydrochloride Chemical Structure

CAS No. : 1035979-44-2

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1 mg USD 180 In-stock
5 mg USD 520 In-stock
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Based on 5 publication(s) in Google Scholar

Other Forms of Sarecycline hydrochloride:

Sarecycline hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Sarecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Sarecycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

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    • Biological Activity

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    • References

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    Description

    Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne [1][2][3][4][5][6].

    IC50 & Target

    Tetracycline

     

    In Vitro

    Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml.[1]
    Sarecycline, exhibits activity against the macrolide-resistant organisms[1].
    Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sarecycline hydrochloride Related Antibodies
    In Vivo

    Sarecycline hydrochloride (0.33-9  mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
    Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
    Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
    Dosage: 0.33, 1, 3, or 9 mg/kg
    Administration: Intravenously
    Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
    Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
    Clinical Trial
    Molecular Weight

    523.96

    Formula

    C24H30ClN3O8
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    [H]Cl.O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C=CC(CN(C)OC)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (190.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9085 mL 9.5427 mL 19.0854 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.27%

    COA (255 KB) HNMR (475 KB) RP-HPLC (258 KB) LCMS (95 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9085 mL 9.5427 mL 19.0854 mL 47.7136 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL 9.5427 mL
    10 mM 0.1909 mL 0.9543 mL 1.9085 mL 4.7714 mL
    15 mM 0.1272 mL 0.6362 mL 1.2724 mL 3.1809 mL
    20 mM 0.0954 mL 0.4771 mL 0.9543 mL 2.3857 mL
    25 mM 0.0763 mL 0.3817 mL 0.7634 mL 1.9085 mL
    30 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5905 mL
    40 mM 0.0477 mL 0.2386 mL 0.4771 mL 1.1928 mL
    50 mM 0.0382 mL 0.1909 mL 0.3817 mL 0.9543 mL
    60 mM 0.0318 mL 0.1590 mL 0.3181 mL 0.7952 mL
    80 mM 0.0239 mL 0.1193 mL 0.2386 mL 0.5964 mL
    100 mM 0.0191 mL 0.0954 mL 0.1909 mL 0.4771 mL
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    Sarecycline hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sarecycline1035979-44-2P-005672P005672P 005672AntibioticBacterialDNA/RNA SynthesisAcneInflammationTetracyclinetetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

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