1. Anti-infection
    Cell Cycle/DNA Damage
  2. Antibiotic
    Bacterial
    DNA/RNA Synthesis
  3. Sarecycline hydrochloride

Sarecycline hydrochloride 

Cat. No.: HY-13858A Purity: 98.40%
Handling Instructions

Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.

For research use only. We do not sell to patients.

Sarecycline hydrochloride Chemical Structure

Sarecycline hydrochloride Chemical Structure

CAS No. : 1035979-44-2

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10 mM * 1 mL in DMSO USD 231 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Description

Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3].

In Vitro

Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms[1].
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
Dosage: 0.33, 1, 3, or 9 mg/kg
Administration: Intravenously
Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
Clinical Trial
Molecular Weight

523.96

Formula

C₂₄H₃₀ClN₃O₈

CAS No.

1035979-44-2

SMILES

[H]Cl.O[[email protected]]12[[email protected]](C[[email protected]@]3([H])C(C(C4=C(O)C=CC(CN(C)OC)=C4C3)=O)=C2O)([H])[[email protected]@H](C(O)=C(C1=O)C(N)=O)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

SarecyclineAntibioticBacterialDNA/RNA Synthesistetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

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Sarecycline hydrochloride
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