1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
    Autophagy
  2. Microtubule/Tubulin
    Apoptosis
    Autophagy
  3. Deoxypodophyllotoxin

Deoxypodophyllotoxin 

Cat. No.: HY-N2500
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Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons.

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Deoxypodophyllotoxin Chemical Structure

Deoxypodophyllotoxin Chemical Structure

CAS No. : 19186-35-7

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Description

Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis[1]. Deoxypodophyllotoxin induces cell autophagy and apoptosis[2]. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons[3].

In Vitro

Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively[1].
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners[1].
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity[1].

Apoptosis Analysis[1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Induced apoptosis in SGC-7901 Cells.

Cell Cycle Analysis[1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Induced G2/M cell cycle arrest in SGC-7901 Cells

Western Blot Analysis[1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins.
In Vivo

Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively[1].

Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells[1]
Dosage: 5, 10, and 20 mg/kg
Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days
Result: Inhibited the growth of gastric cancer tumors.
Molecular Weight

398.41

Formula

C₂₂H₂₂O₇

CAS No.

19186-35-7

SMILES

O=C1[[email protected]]2([H])[[email protected]](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC(OCO5)=C5C=C4C[[email protected]@]2([H])CO1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Deoxypodophyllotoxin
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