1. Anti-infection
  2. Bacterial

Cloxacillin sodium monohydrate 

Cat. No.: HY-B0466 Purity: >98.0%
Handling Instructions

Cloxacillin sodium monohydrate is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.

For research use only. We do not sell to patients.

Cloxacillin sodium monohydrate Chemical Structure

Cloxacillin sodium monohydrate Chemical Structure

CAS No. : 7081-44-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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  • Biological Activity

  • Technical Information

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Description

Cloxacillin sodium monohydrate is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. Target: Antibacterial Cloxacillin sodium (Cloxacap) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin. Cloxacillin sodium exerts a bactericidal action against susceptible microorganisms during the stage of active multiplication. Cloxacillin sodium acts through the inhibition of biosynthesis of cell wall mucopeptides. Cloxacillin sodium is readily absorbed following i.m. administration and rapidly reaches therapeutically effective blood levels. Serum levels are approximately proportional to dosage. Peak plasma concentrations of 15 ug/ml have been observed 30 minutes after an i.m. injection of cloxacillin (Cloxapen, Cloxacap and Orbenin) 500 mg; plasma concentrations may be doubled by administration of a doubled dose. At the end of a 3-hour i.v. infusion of cloxacillin (Cloxapen, Cloxacap and Orbenin) 250 mg given to normal subjects, its plasma concentrations were 15 ug/ml. After 2 hours, plasma concentrations were 0.6 ug/ml [1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.14 mM; Need ultrasonic)

H2O : 50 mg/mL (105.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1014 mL 10.5069 mL 21.0137 mL
5 mM 0.4203 mL 2.1014 mL 4.2027 mL
10 mM 0.2101 mL 1.0507 mL 2.1014 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

References
Molecular Weight

475.88

Formula

C₁₉H₁₉ClN₃NaO₆S

CAS No.

7081-44-9

SMILES

[O-]C([[email protected]@H]1N2[[email protected]@](SC1(C)C)([H])[[email protected]@H](C2=O)NC(C(C(C(C=CC=C3)=C3Cl)=NO4)=C4C)=O)=O.[Na+].O

Storage

4°C, protect from light, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Cloxacillin sodium monohydrate
Cat. No.:
HY-B0466
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Cloxacillin sodium monohydrate

Cat. No.: HY-B0466