1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cloxacillin sodium monohydrate

Cloxacillin sodium monohydrate 

Cat. No.: HY-B0466 Purity: 98.57%
Handling Instructions

Cloxacillin sodium monohydrate exhibits antibiotic efficacy, with a MIC of 256 mg/L for Staphylococcus aureus 25923.

For research use only. We do not sell to patients.

Cloxacillin sodium monohydrate Chemical Structure

Cloxacillin sodium monohydrate Chemical Structure

CAS No. : 7081-44-9

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

Cloxacillin sodium monohydrate exhibits antibiotic efficacy, with a MIC of 256 mg/L for Staphylococcus aureus 25923[1][2][3].

In Vitro

Cloxacillin is an antibiotic useful for the study of a number of bacterial infections[1].

Cell Viability Assay[1]

Cell Line: Strains M12 and M60.
Concentration: 0.5 μg/mL.
Incubation Time: 4-24 h.
Result: Significantly reduced the bacterial numbers.
In Vivo

Cloxacillin sodium (50 mg/kg, Subcutaneously) results a significant antibiotic efficacy against S. aureus[3] .

Animal Model: Mice[2].
Dosage: 10 mg/kg (Pharmacological Analysis).
Administration: Given subcutaneously.
Result: Reached a maximal concentration in plasma of 8.4 μg/mL at 10 min and had a half-life of approximately 15 min.
Animal Model: Mice injected with approximately 2 × 106 CFU of bacteria in 0.1 mL saline were aseptically injected into the right thigh muscle[3].
Dosage: 0–500 mg/kg.
Administration: Subcutaneously in the nuchal region at 1 h after infection.
Result: Resulted in a significant decrease in the number of viable S. aureus measured 18 h thereafter.
Clinical Trial
Molecular Weight

475.88

Formula

C₁₉H₁₉ClN₃NaO₆S

CAS No.

7081-44-9

SMILES

O=C(C(C(C(C=CC=C1)=C1Cl)=NO2)=C2C)N[[email protected]]3[[email protected]](SC(C)(C)[[email protected]@H]4C(O[Na])=O)([H])N4C3=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.14 mM; Need ultrasonic)

H2O : 50 mg/mL (105.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1014 mL 10.5069 mL 21.0137 mL
5 mM 0.4203 mL 2.1014 mL 4.2027 mL
10 mM 0.2101 mL 1.0507 mL 2.1014 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Cloxacillin sodiumBacterialAntibioticInhibitorinhibitorinhibit

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Cloxacillin sodium monohydrate
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HY-B0466
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