1. MAPK/ERK Pathway
    Apoptosis
  2. p38 MAPK
    Apoptosis
  3. Cycloartenol

Cycloartenol 

Cat. No.: HY-N7255
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Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development.

For research use only. We do not sell to patients.

Cycloartenol Chemical Structure

Cycloartenol Chemical Structure

CAS No. : 469-38-5

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Description

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

In Vitro

Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].

Molecular Weight

426.72

Formula

C₃₀H₅₀O

CAS No.

469-38-5

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Keywords:

Cycloartenolp38 MAPKApoptosisanti-inflammatoryanti-tumorantioxidantantibiosisanti-alzheimer'sphosphorylationantiproliferativemigrationgliomacellsInhibitorinhibitorinhibit

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