1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. (R)-Larotrectinib

(R)-Larotrectinib (Synonyms: (R)-LOXO-101; (R)-ARRY-470)

Cat. No.: HY-12866B
Handling Instructions

(R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases

For research use only. We do not sell to patients.

(R)-Larotrectinib Chemical Structure

(R)-Larotrectinib Chemical Structure

CAS No. : 1223404-68-9

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Description

(R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1]

IC50 & Target

TrkA

28.5 nM (IC50)

Molecular Weight

428.44

Formula

C21H22F2N6O2

CAS No.
SMILES

O=C(N1C[[email protected]](O)CC1)NC2=C3N=C(N4[[email protected]@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(R)-Larotrectinib
Cat. No.:
HY-12866B
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