1223404-68-9
1223404-68-9
Chemical Structure
(R)-Larotrectinib
Synonym(s): (R)-LOXO-101; (R)-ARRY-470
- CAS No.: 1223404-68-9
- Formula:C21H22F2N6O2
- Molecular Weight:428.44
IUPAC Name: (R)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
InChIKey: NYNZQNWKBKUAII-RDTXWAMCSA-N
SMILES: O=C(N1C[C@H](O)CC1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2
Biological Activity: (R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1]
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(R)-Larotrectinib | (R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases | |||||||||||||||||||||
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References
Keywords
