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Cat. No.: HY-P1330

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Purotoxin 1

Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp.

For research use only. We do not sell to patients.

CAS No.: 1396322-38-5
Formula: C₁₅₅H₂₄₉N₅₁O₄₇S₈
Molecular Weight:3835.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Purotoxin 1 Chemical Structure

CAS No.: 1396322-38-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All P2X Receptor Isoforms :

Chemical Information

CAS No. 1396322-38-5
Molecular Weight 3835.47
Formula C₁₅₅H₂₄₉N₅₁O₄₇S₈
Sequence

Gly-Tyr-Cys-Ala-Glu-Lys-Gly-Ile-Arg-Cys-Asp-Asp-Ile-His-Cys-Cys-Thr-Gly-Leu-Lys-Cys-Lys-Cys-Asn-Ala-Ser-Gly-Tyr-Asn-Cys-Val-Cys-Arg-Lys-Lys-NH2 (Disulfide bridge: Cys3-Cys16, Cys10-Cys21, Cys15-Cys32, Cys23-Cys30)
Sequence Shortening

GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK-NH2 (Disulfide bridge: Cys3-Cys16, Cys10-Cys21, Cys15-Cys32, Cys23-Cys30)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Grishin EV, et al. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann Neurol. 2010 May;67(5):680-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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