1. Anti-infection
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Bacterial
    HIV
    Reactive Oxygen Species
  3. Methyl gallate

Methyl gallate (Synonyms: Gallincin; NSC 363001)

Cat. No.: HY-N2010 Purity: 99.96%
Handling Instructions

Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

For research use only. We do not sell to patients.

Methyl gallate Chemical Structure

Methyl gallate Chemical Structure

CAS No. : 99-24-1

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10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

IC50 & Target

Bacterial[1]

In Vitro

The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[1]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[2]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[3].

Molecular Weight

184.15

Formula

C₈H₈O₅

CAS No.

99-24-1

SMILES

O=C(OC)C1=CC(O)=C(O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (543.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4304 mL 27.1518 mL 54.3036 mL
5 mM 1.0861 mL 5.4304 mL 10.8607 mL
10 mM 0.5430 mL 2.7152 mL 5.4304 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Methyl gallateGallincin NSC 363001NSC363001NSC 363001NSC-363001BacterialHIVReactive Oxygen SpeciesHuman immunodeficiency virusInhibitorinhibitorinhibit

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Methyl gallate
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HY-N2010
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