Anti-inflammatory agent 31
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.
For research use only. We do not sell to patients.
- CAS No.: 3051838-54-8
- Formula: C19H30O3
- Molecular Weight:306.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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ERK1 |
ERK2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
66.95 μM
Compound: 17
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-glo assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-glo assay
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[PMID: 32712435] |
| L02 | CC50 |
30.12 μM
Compound: 17
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Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-glo assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-glo assay
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[PMID: 32712435] |
Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner[1].
Anti-inflammatory agent 31 reacts as a quick rate (KGSH=0.076 M-1.h-1) and long half-live (T1/2=6.47 h)[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC50 of 14.68, 26.25 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW-blueTM cells
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Concentration:5, 10, 20 μM
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Incubation Time:24 hours
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Result:Inhibited the LPS-induced NF-κB activity and indicated the anti-inflammatory properties.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced acute lung injury (ALI) mouse model (female BALB/c mice; 7-week-old)[1]
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Dosage:0.3, 1.0 mg/kg
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Administration:Intraperitoneal injection 1 h after LPS challenge; twice daily for 4 days
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Result:Alleviated LPS-induced acute lung injury.
Chemical Information
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CAS No. 3051838-54-8
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Molecular Weight 306.44
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Formula C19H30O3
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SMILES
CC(/C=C/C[C@@H]1C(CC[C@]2([H])[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 31 Related Classifications
HY-150587 Related Classifications
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