2. MAPK/ERK Pathway Stem Cell/Wnt NF-κB
  3. ERK NF-κB
  4. Anti-inflammatory agent 31

Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.

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Anti-inflammatory agent 31 Chemical Structure

Anti-inflammatory agent 31 Chemical Structure

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Anti-inflammatory agent 31 Related Antibodies

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Description

Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver[1].

IC50 & Target

ERK1

 

ERK2

 

In Vitro

Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner[1].
Anti-inflammatory agent 31 reacts as a quick rate (KGSH=0.076 M-1.h-1) and long half-live (T1/2=6.47 h)[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC50 of 14.68, 26.25 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 31 Related Antibodies

Immunofluorescence[1]

Cell Line: RAW-blueTM cells
Concentration: 5, 10, 20 μM
Incubation Time: 24 hours
Result: Inhibited the LPS-induced NF-κB activity and indicated the anti-inflammatory properties.
In Vivo

Anti-inflammatory agent 31 (enone 17) (i.p.; 0.3, 1.0 mg/kg) decreases total white blood cell and neutrophils counts, and alleviates LPS-induced acute lung injury in a dose-dependent manner in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury (ALI) mouse model (female BALB/c mice; 7-week-old)[1]
Dosage: 0.3, 1.0 mg/kg
Administration: Intraperitoneal injection 1 h after LPS challenge; twice daily for 4 days
Result: Alleviated LPS-induced acute lung injury.
Molecular Weight

306.44

Formula

C19H30O3
SMILES

CC(/C=C/C[C@@H]1C(CC[C@]2([H])[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 31ERKNF-κBExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBanti-inflammatoryandrographolidecovalent inhibitorMichael additionreversibilityliverInhibitorinhibitorinhibit

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