1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Atracurium besylate

Atracurium besylate (Synonyms: BW-33A)

Cat. No.: HY-B0292A Purity: 98.89%
Handling Instructions

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.

For research use only. We do not sell to patients.

Atracurium besylate Chemical Structure

Atracurium besylate Chemical Structure

CAS No. : 64228-81-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
500 mg USD 288 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg. Target: nAChR Atracurium besylate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent [1]. A 14C radiolabeled metabolism study in cats confirmed the lack of hepatic or renal involvement in the metabolism of atracurium: radioactivity eliminated in bile and urine was predominantly from metabolites rather than the unchanged parent drug [2].

Clinical Trial
Molecular Weight

1243.48

Formula

C₆₅H₈₂N₂O₁₈S₂

CAS No.
SMILES

O=S(C1=CC=CC=C1)([O-])=O.O=C(OCCCCCOC(CC[N+]2(C)C(CC3=CC=C(OC)C(OC)=C3)C4=C(C=C(OC)C(OC)=C4)CC2)=O)CC[N+]5(C)C(CC6=CC=C(OC)C(OC)=C6)C7=C(C=C(OC)C(OC)=C7)CC5.O=S(C8=CC=CC=C8)([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (80.42 mM; Need ultrasonic)

H2O : 33.33 mg/mL (26.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8042 mL 4.0210 mL 8.0419 mL
5 mM 0.1608 mL 0.8042 mL 1.6084 mL
10 mM 0.0804 mL 0.4021 mL 0.8042 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (80.42 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.01 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.89%

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Keywords:

Atracurium besylateBW-33AnAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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Product Name:
Atracurium besylate
Cat. No.:
HY-B0292A
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