1. Membrane Transporter/Ion Channel
  2. Na+/H+ Exchanger (NHE)
  3. Tenapanor

Tenapanor  (Synonyms: AZD1722; RDX5791)

Cat. No.: HY-15991 Purity: 98.04%
COA Handling Instructions

Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia.

For research use only. We do not sell to patients.

Tenapanor Chemical Structure

Tenapanor Chemical Structure

CAS No. : 1234423-95-0

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 378 In-stock
Solution
10 mM * 1 mL in DMSO USD 378 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 145 In-stock
25 mg USD 300 In-stock
50 mg USD 470 In-stock
100 mg USD 750 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Tenapanor:

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  • Biological Activity

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Description

Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia[1][2].

IC50 & Target

IC50: 5 nM (NHE3, human), 10 nM (NHE3, rat)[1]

In Vivo

Tenapanor (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1].
Tenapanor (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (intestinal loop model)[1]
Dosage: 0.15, 0.5 mg/kg
Administration: P.o.
Result: Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.
Animal Model: 8 weeks, 250 g male Sprague–Dawley rats[2]
Dosage: 0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
Administration: Oral gavage; twice-daily for 11 consecutive days
Result: Significantly augmented the reduction in urinary phosphorus excretion.
Clinical Trial
Molecular Weight

1145.05

Formula

C50H66Cl4N8O10S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCNS(=O)(C1=CC=CC([C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)=C1)=O)NCCCCNC(NCCOCCOCCNS(=O)(C4=CC=CC([C@@H]5CN(C)CC6=C5C=C(Cl)C=C6Cl)=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (43.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8733 mL 4.3666 mL 8.7332 mL
5 mM 0.1747 mL 0.8733 mL 1.7466 mL
10 mM 0.0873 mL 0.4367 mL 0.8733 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (2.18 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (2.18 mM); Clear solution

  • 4.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (2.18 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.65%

References
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Tenapanor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Tenapanor
Cat. No.:
HY-15991
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