Tenapanor hydrochloride
Based on 8 publication(s) in Google Scholar
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 1234365-97-9
- Formula: C50H68Cl6N8O10S2
- Molecular Weight:1217.97
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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FDA-Approved Drug Library
HY-L022
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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FDA Approved & Pharmacopeial Drug Library
HY-L066
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Drug Repurposing Compound Library Plus
HY-L035P
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FDA-Approved Drug Library Plus
HY-L022P
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FDA-Approved Drug Library Mini
HY-L022M
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Tenapanor hydrochloride
More- J Exp Med. 2021 Nov 1;218(11):e20210479. [Abstract]
- JCI Insight. 2021 Jun 8;6(11):e147699. [Abstract]
- Int J Mol Sci. 2026 Apr 21;27(8):3683. [Abstract]
- Neuropharmacology. 2026 Apr 1:287:110829. [Abstract]
- J Virol. 2025 Jun 17;99(6):e0189424. [Abstract]
- J Virol. 2022 Nov 23;96(22):e0147322. [Abstract]
- Vet Microbiol. 2021 Dec:263:109263. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 19:785:152676. [Abstract]
Biological Activity
Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats (intestinal loop model)[1]
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Dosage:0.15, 0.5 mg/kg
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Administration:P.o.
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Result:Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.
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Animal Model:8 weeks, 250 g male Sprague–Dawley rats[2]
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Dosage:0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
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Administration:Oral gavage; twice-daily for 11 consecutive days
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Result:Significantly augmented the reduction in urinary phosphorus excretion.
Chemical Information
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CAS No. 1234365-97-9
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Appearance Solid
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Molecular Weight 1217.97
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Formula C50H68Cl6N8O10S2
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Color White to off-white
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SMILES
O=S(C1=CC=CC([C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)=C1)(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C4=CC=CC([C@@H]5CN(C)CC6=C5C=C(Cl)C=C6Cl)=C4)=O)=O)=O)=O.[H]Cl.[H]Cl
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Synonyms
AZD1722 hydrochloride; RDX5791 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Exp Med
Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C. [Abstract]2021 Nov 1;218(11):e20210479. PMID: 34546338 -
JCI Insight
SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. [Abstract]2021 Jun 8;6(11):e147699. PMID: 34100381 -
Int J Mol Sci
Analysis of Phosphate Transporters in Peritoneal Cells and Tissues and Their Transport Kinetics In Vitro. [Abstract]2026 Apr 21;27(8):3683. PMID: 42074321 -
Neuropharmacology
Acetazolamide alleviates motion sickness by inhibiting inner ear carbonic anhydrase 2 and reducing endolymph volume. [Abstract]2026 Apr 1:287:110829. PMID: 41512954 -
J Virol
Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation. [Abstract]2025 Jun 17;99(6):e0189424. PMID: 40340398 -
J Virol
Transmissible Gastroenteritis Virus Nucleocapsid Protein Interacts with Na+/H+ Exchanger 3 To Reduce Na+/H+ Exchanger Activity and Promote Piglet Diarrhea. [Abstract]2022 Nov 23;96(22):e0147322. PMID: 36342433 -
Vet Microbiol
Decreased NHE3 activity in intestinal epithelial cells in TGEV and PEDV-induced piglet diarrhea. [Abstract]2021 Dec:263:109263. PMID: 34749283 -
Biochem Biophys Res Commun
Glucose transports in the ileum: mechanism, regulation and physiological role of ileal glucose absorption. [Abstract]2025 Sep 19:785:152676. PMID: 41005286
Solvent & Solubility
DMSO : 100 mg/mL (82.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (16.42 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (4.11 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. King AJ, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. [Content Brief]
[2]. King AJ, et al. Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F133-F144. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8210 mL | 4.1052 mL | 8.2104 mL | 20.5260 mL |
| 5 mM | 0.1642 mL | 0.8210 mL | 1.6421 mL | 4.1052 mL | |
| 10 mM | 0.0821 mL | 0.4105 mL | 0.8210 mL | 2.0526 mL | |
| 15 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL | 1.3684 mL | |
| DMSO | 20 mM | 0.0411 mL | 0.2053 mL | 0.4105 mL | 1.0263 mL |
| 25 mM | 0.0328 mL | 0.1642 mL | 0.3284 mL | 0.8210 mL | |
| 30 mM | 0.0274 mL | 0.1368 mL | 0.2737 mL | 0.6842 mL | |
| 40 mM | 0.0205 mL | 0.1026 mL | 0.2053 mL | 0.5131 mL | |
| 50 mM | 0.0164 mL | 0.0821 mL | 0.1642 mL | 0.4105 mL | |
| 60 mM | 0.0137 mL | 0.0684 mL | 0.1368 mL | 0.3421 mL | |
| 80 mM | 0.0103 mL | 0.0513 mL | 0.1026 mL | 0.2566 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tenapanor hydrochloride Related Classifications
HY-15991A Related Classifications
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