Vecuronium bromide
Based on 1 Customer Validation
Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 50700-72-6
- Formula: C34H57BrN2O4
- Molecular Weight:637.73
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
1.9 μM
Compound: vecuronium bromide
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Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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[PMID: 23241029] |
| HEK293 | IC50 |
25.2 μM
Compound: vecuronium bromide
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Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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[PMID: 23241029] |
| HEK293 | IC50 |
3.5 μM
Compound: vecuronium bromide
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Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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[PMID: 23241029] |
Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells[1]. Vecuronium bromide (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner[2]. Vecuronium bromide (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Lung cancer cell line (A549)
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Concentration:0-15 μM
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Incubation Time:72 hours
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Result:Inhibited cell proliferation at concentrations ranging from 5.0 μM to 15 μM.
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Cell Line:Lung cancer cell line (A549)
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Concentration:0-15 μM
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Incubation Time:72 hours
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Result:Resulted in a decrease in cell viability from 10 μM to 15 Μm by combining with cisplatin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wister rats weighing 250-350 g[3]
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Dosage:0-5 μM
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Administration:Intravenous injection; every 30 min; 2 hours
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Result:Significantly diminished CSNA response to hypoxia at the concentration of 5 μM and reduced carotid sinus nerve response to ACh at 0.5 μM.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 50700-72-6
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Appearance Solid
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Molecular Weight 637.73
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Formula C34H57BrN2O4
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Color White to off-white
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SMILES
C[C@@]1([C@H]2OC(C)=O)[C@](C[C@@H]2[N+]3(CCCCC3)C)([H])[C@@](CC[C@]4([H])[C@@]5(C[C@H](N6CCCCC6)[C@@H](OC(C)=O)C4)C)([H])[C@]5([H])CC1.[Br-]
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Synonyms
ORG NC 45
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (156.81 mM)
DMSO : 83.33 mg/mL (130.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. K Uryu, et al. Inhibition by neuromuscular blocking drugs of norepinephrine transporter in cultured bovine adrenal medullary cells. Anesth Analg. 2000 Sep;91(3):546-51. [Content Brief]
[3]. Ayuko Igarashi,et al. Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesth Analg. 2002 Jan;94(1):117-22, table of contents. [Content Brief]
[4]. Meretoja, O.A., Vecuronium infusion requirements in pediatric patients during fentanyl-N2O-O2 anesthesia. Anesth Analg, 1989. 68(1): p. 20-4. [Content Brief]
[5]. Agoston, S., et al., The neuromuscular blocking action of ORG NC 45, a new pancuronium derivative, in anaesthetized patients. A pilot study. Br J Anaesth, 1980. 52 Suppl 1: p. 53S-59S. [Content Brief]
[6]. Shingu, K., et al., [Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients]. Masui, 2006. 55(9): p. 1140-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.5681 mL | 7.8403 mL | 15.6806 mL | 39.2015 mL |
| 5 mM | 0.3136 mL | 1.5681 mL | 3.1361 mL | 7.8403 mL | |
| 10 mM | 0.1568 mL | 0.7840 mL | 1.5681 mL | 3.9202 mL | |
| 15 mM | 0.1045 mL | 0.5227 mL | 1.0454 mL | 2.6134 mL | |
| 20 mM | 0.0784 mL | 0.3920 mL | 0.7840 mL | 1.9601 mL | |
| 25 mM | 0.0627 mL | 0.3136 mL | 0.6272 mL | 1.5681 mL | |
| 30 mM | 0.0523 mL | 0.2613 mL | 0.5227 mL | 1.3067 mL | |
| 40 mM | 0.0392 mL | 0.1960 mL | 0.3920 mL | 0.9800 mL | |
| 50 mM | 0.0314 mL | 0.1568 mL | 0.3136 mL | 0.7840 mL | |
| 60 mM | 0.0261 mL | 0.1307 mL | 0.2613 mL | 0.6534 mL | |
| 80 mM | 0.0196 mL | 0.0980 mL | 0.1960 mL | 0.4900 mL | |
| 100 mM | 0.0157 mL | 0.0784 mL | 0.1568 mL | 0.3920 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Vecuronium bromide Related Classifications
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