1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Adiphenine hydrochloride

Adiphenine hydrochloride 

Cat. No.: HY-B0379A Purity: 99.62%
Handling Instructions

Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 µM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride can be used as a local anesthetic.

For research use only. We do not sell to patients.

Adiphenine hydrochloride Chemical Structure

Adiphenine hydrochloride Chemical Structure

CAS No. : 50-42-0

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Description

Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 µM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride can be used as a local anesthetic[1][2].

IC50 & Target

IC50: 1.9 µM (α1), 1.8 µM (α3β4 nAChR), 3.7 µM (α4β2 nAChR), 6.3 µM (α4β4 nAChR)[1]

Molecular Weight

347.88

Formula

C₂₀H₂₆ClNO₂

CAS No.

50-42-0

SMILES

O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (287.46 mM)

H2O : ≥ 50 mg/mL (143.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8746 mL 14.3728 mL 28.7455 mL
5 mM 0.5749 mL 2.8746 mL 5.7491 mL
10 mM 0.2875 mL 1.4373 mL 2.8746 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (9.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (9.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (9.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AdipheninenAChRNicotinic acetylcholine receptorsnicotinicacetylcholinelocalanestheticInhibitorinhibitorinhibit

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Adiphenine hydrochloride
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HY-B0379A
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