2. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. ROR
  4. TMP780

TMP780 

Cat. No.: HY-102075B Purity: 99.51%
COA Handling Instructions

TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders.

For research use only. We do not sell to patients.

TMP780 Chemical Structure

TMP780 Chemical Structure

CAS No. : 1422053-03-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 490 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 490 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TMP780:

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Description

TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders[1].

IC50 & Target

IC50: 13 nM (RORγt)[1]
Molecular Weight

494.58

Appearance

Solid

Formula

C31H30N2O4
CAS No.
SMILES

O=C(N[[email protected]](C1=CC=C(C)C=C1C)C2=CC=CC=C2)CC3=CC=C(OC([[email protected]@H](C4=C(C)ON=C4C)O)=C5)C5=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (444.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0219 mL 10.1096 mL 20.2192 mL
5 mM 0.4044 mL 2.0219 mL 4.0438 mL
10 mM 0.2022 mL 1.0110 mL 2.0219 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5.5 mg/mL (11.12 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.5 mg/mL (11.12 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TMP7801422053-03-9TMP 780TMP-780RORRAR-related orphan receptorRORγtcutaneou,s inflammatorydisordersInhibitorinhibitorinhibit

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