Art. -Nr.: HY-N7036

Rhamnetin

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity.

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Reinheit: 99.18%
CAS. Nr.: 90-19-7
Formel: C₁₆H₁₂O₇
Molecular Weight:316.27

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Rhamnetin Chemical Structure

CAS. Nr.: 90-19-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Phospholipase Isoform-spezifische Produkte anzeigen :

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.8 μM Compound: 3	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19278239]
Monocyte	IC₅₀	22 μM Compound: Rhamnetin	Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA	[PMID: 10096854]

In Vitro

Rhamnetin (0-10 μM, 24-48 h) inhibits the proliferation of cancer cell SKOV3 with an an IC₅₀ of 1.22 μM (24 h)^[2].
Rhamnetin (0-10 μM, 24 h) arrests the cell cycle of SKOV3 at G1 phase, and induces apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

SKOV3
Concentration:

0-10 μM
Incubation Time:

24-48 h
Result:

Inhibited the cell viability of SKOV3.

Cell Cycle Analysis^[2]

Cell Line:

SKOV3
Concentration:

0-10 μM
Incubation Time:

24 h
Result:

Arrested the cell cycle at G1 phase.

In Vivo

Rhamnetin (50-200 mg/kg, ip, once daily for 21 days) improves cognitive dysfunction after traumatic brain injury in rats and inhibits inflammatory response and oxidative stress in the hippocampus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat traumatic brain injury model^[3]
Dosage:

50-200 mg/kg
Administration:

ip, once daily for 21 days
Result:

Improved the spatial learning and memory ability of rats.
Reduced the levels of TNF-α, IL-1β, IL-6, IL-8, hs-CRP, MDA and H₂O₂ in the hippocampus.
Increased the levels of IL-10, SOD, GSH-Px in the hippocampus.

Chemical Information

CAS. Nr. 90-19-7
Appearance Solid
Molecular Weight 316.27
Formel C₁₆H₁₂O₇
Color White to yellow
SMILES

OC1=C(C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(OC)=C3)C1=O
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- Umbelliferae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Chem Biodivers

Rhamnetin Identified as a Potent Multidrug Resistance Reversal Agent From Xinjiang Euphorbia: Integrated Network Pharmacology, Molecular Simulation, and In Vitro Validation. [Abstract]

2026 Apr;23(4):e01952. PMID: 42037539
SSRN

2025 May 7.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (632.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1619 mL

15.8093 mL

31.6186 mL

5 mM

0.6324 mL

3.1619 mL

6.3237 mL

10 mM

0.3162 mL

1.5809 mL

3.1619 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9). [Content Brief]

[2]. Bharadwaj KK, et al., Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein. J Biomol Struct Dyn. 2024;42(24):13421-13436. [Content Brief]

[3]. Zhang W, et al., Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury. Cent Eur J Immunol. 2015;40(1):35-41. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1619 mL	15.8093 mL	31.6186 mL	79.0464 mL
	5 mM	0.6324 mL	3.1619 mL	6.3237 mL	15.8093 mL
	10 mM	0.3162 mL	1.5809 mL	3.1619 mL	7.9046 mL
	15 mM	0.2108 mL	1.0540 mL	2.1079 mL	5.2698 mL
	20 mM	0.1581 mL	0.7905 mL	1.5809 mL	3.9523 mL
	25 mM	0.1265 mL	0.6324 mL	1.2647 mL	3.1619 mL
	30 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6349 mL
	40 mM	0.0790 mL	0.3952 mL	0.7905 mL	1.9762 mL
	50 mM	0.0632 mL	0.3162 mL	0.6324 mL	1.5809 mL
	60 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3174 mL
	80 mM	0.0395 mL	0.1976 mL	0.3952 mL	0.9881 mL
	100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.7905 mL

Keywords

Rhamnetin

2 Cited Publications

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Rhamnetin

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Publications Citing Use of MedChemExpress (MCE) Rhamnetin

Alle Phospholipase Isoform-spezifische Produkte anzeigen

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Rhamnetin Related Classifications

HY-N7036 Related Classifications