Rhamnetin
Based on 2 publication(s) in Google Scholar
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity.
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- Purity: 99.18%
- CAS No.: 90-19-7
- 화학식: C16H12O7
- 분자량:316.27
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Rhamnetin
MoreAll Phospholipase Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
7.8 μM
Compound: 3
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Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
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[PMID: 19278239] |
| Monocyte | IC50 |
22 μM
Compound: Rhamnetin
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Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
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[PMID: 10096854] |
Rhamnetin (0-10 μM, 24-48 h) inhibits the proliferation of cancer cell SKOV3 with an an IC50 of 1.22 μM (24 h)[2].
Rhamnetin (0-10 μM, 24 h) arrests the cell cycle of SKOV3 at G1 phase, and induces apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat traumatic brain injury model[3]
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Dosage:50-200 mg/kg
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Administration:ip, once daily for 21 days
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Result:Improved the spatial learning and memory ability of rats.
Reduced the levels of TNF-α, IL-1β, IL-6, IL-8, hs-CRP, MDA and H2O2 in the hippocampus.
Increased the levels of IL-10, SOD, GSH-Px in the hippocampus.
Chemical Information
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CAS No. 90-19-7
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Appearance Solid
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분자량 316.27
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화학식 C16H12O7
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Color White to yellow
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SMILES
OC1=C(C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(OC)=C3)C1=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 200 mg/mL (632.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9). [Content Brief]
[2]. Bharadwaj KK, et al., Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein. J Biomol Struct Dyn. 2024;42(24):13421-13436. [Content Brief]
[3]. Zhang W, et al., Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury. Cent Eur J Immunol. 2015;40(1):35-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1619 mL | 15.8093 mL | 31.6186 mL | 79.0464 mL |
| 5 mM | 0.6324 mL | 3.1619 mL | 6.3237 mL | 15.8093 mL | |
| 10 mM | 0.3162 mL | 1.5809 mL | 3.1619 mL | 7.9046 mL | |
| 15 mM | 0.2108 mL | 1.0540 mL | 2.1079 mL | 5.2698 mL | |
| 20 mM | 0.1581 mL | 0.7905 mL | 1.5809 mL | 3.9523 mL | |
| 25 mM | 0.1265 mL | 0.6324 mL | 1.2647 mL | 3.1619 mL | |
| 30 mM | 0.1054 mL | 0.5270 mL | 1.0540 mL | 2.6349 mL | |
| 40 mM | 0.0790 mL | 0.3952 mL | 0.7905 mL | 1.9762 mL | |
| 50 mM | 0.0632 mL | 0.3162 mL | 0.6324 mL | 1.5809 mL | |
| 60 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3174 mL | |
| 80 mM | 0.0395 mL | 0.1976 mL | 0.3952 mL | 0.9881 mL | |
| 100 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.7905 mL |
Rhamnetin Related Classifications
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