1. GPCR/G Protein
  2. GPR40
    GPR84

PBI-4050 sodium salt (Synonyms: Setogepram (sodium salt))

Cat. No.: HY-100775 Purity: 99.39%
Handling Instructions

PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84.

For research use only. We do not sell to patients.

PBI-4050 sodium salt Chemical Structure

PBI-4050 sodium salt Chemical Structure

CAS No. : 1254472-97-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84.

IC50 & Target

GPR40, GPR84[1]

In Vivo

PBI-4050, a synthetic analogue of a medium–chain length fatty acid, binds to FFA receptor 1 (FFAR1/GPR40) and GPR84. To determine the potential role of PBI-4050 on diabetic kidney disease, The accelerated model of type 2 diabetic nephropathy, eNOS-/- db/db mice are utilized. Mice are treated with either vehicle or PBI-4050 (100 mg/kg) by daily gavage from 8-20 weeks of age. eNOS-/- db/db mice are moderately hypertensive, and PBI-4050 has no effect on blood pressure. Furthermore, compared with vehicle-treated mice, which exhibit a decrease in glomerular filtration rate (GFR) from 8-20 weeks, PBI-4050 preserves GFR. Podocyte number per glomerulus section markedly decreases from 8-20 weeks of age in vehicle-treated mice, while PBI-4050 treatment significantly slows this loss[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (438.10 mM)

DMSO : ≥ 64 mg/mL (280.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3810 mL 21.9048 mL 43.8097 mL
5 mM 0.8762 mL 4.3810 mL 8.7619 mL
10 mM 0.4381 mL 2.1905 mL 4.3810 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Type 2 diabetes eNOS-/- db/db mice on the BKS background are used. Genotyping is performed by PCR. A subset of eNOS-/- db/db male mice (8 weeks old) are randomized to 2 groups. One group is treated with PBI-4050 (100 mg/kg/day, n=10) , and the other group receive vehicle (water, n=12). Both PBI-4050 and water are given via daily gavage from 8-20 weeks. Mice are euthanized at 20 weeks of age. The second set of eNOS-/- db/db male mice are divided into 4 groups (8 mice in each group): vehicle (water), PBI-4050 (100 mg/kg/day), Captopril (0.75 mg/mL in drinking water), and PBI-4050 plus captopril. The treatment is begun at 16 weeks and ended at 24 weeks. The third set of eNOS-/- db/db male mice is divided into 2 groups (8 mice in each group): vehicle (water) and PBI-4050 (100 mg/kg/day). The treatment begins at 16 weeks and lasts up to 30 weeks or until death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

228.26

Formula

C₁₃H₁₇NaO₂

CAS No.

1254472-97-3

SMILES

O=C(O[Na])CC1=CC(CCCCC)=CC=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.39%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PBI-4050 sodium salt
Cat. No.:
HY-100775
Quantity:

PBI-4050 sodium salt

Cat. No.: HY-100775