1. Apoptosis
    Autophagy
    Cell Cycle/DNA Damage
  2. Apoptosis
    Autophagy
    PPAR
  3. Falcarindiol

Falcarindiol 

Cat. No.: HY-N0364
Handling Instructions

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties.

For research use only. We do not sell to patients.

Falcarindiol Chemical Structure

Falcarindiol Chemical Structure

CAS No. : 55297-87-5

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Top Publications Citing Use of Products

Publications Citing Use of MCE Falcarindiol

    Falcarindiol purchased from MCE. Usage Cited in: PLoS One. 2017 Apr 25;12(4):e0176348.

    FAD-induced cell death in breast cancer cells is mediates by ER stress. The western blot analyzed the level of GRP78 in MDA-MB-231 cells treated with indicated concentration of FAD for 24 hours. FAD increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner.

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    Description

    Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2].

    IC50 & Target[1]

    PPARγ

     

    In Vitro

    Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells[1].
    Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells[1].
    Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner[1].
    Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells[2].
    Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    260.37

    Formula

    C₁₇H₂₄O₂

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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