(+)-(3R,8S)-Falcarindiol (Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol)

Name: (+)-(3R,8S)-Falcarindiol
Brand: MedChemExpress
SKU: HY-N1976
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1976 Purity: 98.53%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(+)-(3R,8S)-Falcarindiol ((3R,8S)-Falcarindiol; 3 (R),8 (S),9 (Z)-Falcarindiol) is an orally active polyacetylene anti-mycobacterial agent. (+)-(3R,8S)-Falcarindiol exhibits antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and mycobacteria. Co-administration of (+)-(3R,8S)-Falcarindiol with (3R)-falcarinol alters the composition of gut microbiota, reduces colonic tumor lesions and slows down polyp growth. (+)-(3R,8S)-Falcarindiol can be used in research related to tuberculosis and colorectal cancer.

For research use only. We do not sell to patients.

(+)-(3R,8S)-Falcarindiol Chemical Structure

CAS No. : 225110-25-8

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (+)-(3R,8S)-Falcarindiol:

Falcarindiol In-stock

1 Publications Citing Use of MCE (+)-(3R,8S)-Falcarindiol

•Biochem Biophys Res Commun. 2024 Dec 3:736:150860. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 6 μM (Mycobacterium tuberculosis H37Ra)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	2.9 μg/mL Compound: 8	Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs Inhibition of alpha-MSH-stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs	[PMID: 22450129]
CHO	IC₅₀	117.5 μM Compound: 12	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	[PMID: 16643021]
HEK293	EC₅₀	3.2 μM Compound: Ref 6, Cpd 2	Activation of human PPARgamma expressed in HEK293 cells incubated for 18 hrs by luciferase reporter assay relative to control Activation of human PPARgamma expressed in HEK293 cells incubated for 18 hrs by luciferase reporter assay relative to control	[PMID: 32129622]
HL-60	IC₅₀	8.9 μM Compound: 5	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 15387667]
HT-1080	IC₅₀	13 μM Compound: 5	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 15387667]
Hepatocyte	IC₅₀	> 100 μM Compound: 21	Inhibitory activity against D-GalN-induced cytotoxicity in rat hepatocytes Inhibitory activity against D-GalN-induced cytotoxicity in rat hepatocytes	[PMID: 9873511]
LoVo	IC₅₀	4.3 μM Compound: 5	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 15387667]
LoVo	IC₅₀	> 40 μM Compound: 5	Cytotoxicity against human doxorubicin-resistant LoVo cells after 72 hrs by MTT assay Cytotoxicity against human doxorubicin-resistant LoVo cells after 72 hrs by MTT assay	[PMID: 15387667]

In Vitro

(+)-(3R,8S)-Falcarindiol (0.20-400 µg/mL; 96 h) potently inhibits the growth of Mycobacterium tuberculosis H37Ra, with an IC₅₀ of 6 μM and a MIC of 24 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Co-administration of (+)-(3R,8S)-Falcarindiol (7 µg/g; oral; continuous administration via diet; for 10 weeks) with (3R)-falcarinol significantly alters the composition of low-abundance members in the intestinal microbiota of rats and reduces colonic tumor lesions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	F344 (male, 5 weeks old at arrival, injected with azoxymethane at 8 weeks of age)^[2]
Dosage:	7 µg/g feed (in combination with 7 µg/g feed of (3R)-falcarinol)
Administration:	p.o.; continuous via diet; from 2 weeks before AOM injection until euthanasia
Result:	Significantly altered the composition of the less abundant members in the rat intestinal microbiota, but there was no systematic difference in the relative abundance of the dominant bacteria. Reduced colon tumor lesions.

Molecular Weight

260.37

Formula

C₁₇H₂₄O₂

CAS No.

225110-25-8

Appearance

Liquid (Density: 1.000 g/cm³)

Color

Colorless to light yellow

SMILES

C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (576.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8407 mL	19.2034 mL	38.4069 mL
5 mM	0.7681 mL	3.8407 mL	7.6814 mL
10 mM	0.3841 mL	1.9203 mL	3.8407 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.53%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (242 KB) HNMR (194 KB) CNMR (205 KB) RP-HPLC (496 KB) MS (597 KB)

Handling Instructions (2659 KB)

References

[1]. O'Neill T, et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. J Ethnopharmacol. 2013;147(1):232-237. [Content Brief]

[2]. Kobaek-Larsen M, et al. Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer. BMC Res Notes. 2018;11(1):411. Published 2018 Jun 27. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8407 mL	19.2034 mL	38.4069 mL	96.0172 mL
	5 mM	0.7681 mL	3.8407 mL	7.6814 mL	19.2034 mL
	10 mM	0.3841 mL	1.9203 mL	3.8407 mL	9.6017 mL
	15 mM	0.2560 mL	1.2802 mL	2.5605 mL	6.4011 mL
	20 mM	0.1920 mL	0.9602 mL	1.9203 mL	4.8009 mL
	25 mM	0.1536 mL	0.7681 mL	1.5363 mL	3.8407 mL
	30 mM	0.1280 mL	0.6401 mL	1.2802 mL	3.2006 mL
	40 mM	0.0960 mL	0.4801 mL	0.9602 mL	2.4004 mL
	50 mM	0.0768 mL	0.3841 mL	0.7681 mL	1.9203 mL
	60 mM	0.0640 mL	0.3201 mL	0.6401 mL	1.6003 mL
	80 mM	0.0480 mL	0.2400 mL	0.4801 mL	1.2002 mL
	100 mM	0.0384 mL	0.1920 mL	0.3841 mL	0.9602 mL

(+)-(3R,8S)-Falcarindiol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-(3R,8S)-Falcarindiol225110-25-8(3R,8S)-Falcarindiol 3(R),8(S),9(Z)-FalcarindiolGram-positive bacteriacarrotsHeracleum maximum rootsantimycobacterial bacteriaMycobacterium tuberculosis strain H37RaGram-negative bacteriatuberculosiscolon neoplastic lesionspolypgut microbiotaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

(+)-(3R,8S)-Falcarindiol (Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol)

Customer Review

Other Forms of (+)-(3R,8S)-Falcarindiol:

(+)-(3R,8S)-Falcarindiol Related Antibodies

1 Publications Citing Use of MCE (+)-(3R,8S)-Falcarindiol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

(+)-(3R,8S)-Falcarindiol Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(+)-(3R,8S)-Falcarindiol Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report