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MnTBAP chloride 

Cat. No.: HY-126397 Purity: ≥98.0%
COA Handling Instructions

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

For research use only. We do not sell to patients.

MnTBAP chloride Chemical Structure

MnTBAP chloride Chemical Structure

CAS No. : 55266-18-7

Size Price Stock Quantity
25 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MnTBAP chloride

WB

    MnTBAP chloride purchased from MCE. Usage Cited in: Free Radic Biol Med. 2022 Nov 17;S0891-5849(22)00992-3.

    The decreased protein expression levels of the ferroptosis repressors NRF2, SLC7A11, and GPX4 after cisplatin stimuli are rescued by 84-B10 (40 µM), MnTBAP (80 µM), and Lipro-1 (2 µM) pretreat for 2 h, in TKPT cells.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].

    IC50 & Target[1][2]

    NFκB

     

    In Vitro

    MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
    MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
    Dosage: 10 mg/kg
    Administration: IP; three times per week for twelve weeks
    Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
    Molecular Weight

    879.15

    Formula

    C48H28ClMnN4O8

    CAS No.
    SMILES

    [Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (113.75 mM; Need ultrasonic)

    0.5 M NaOH : 20 mg/mL (22.75 mM; Need ultrasonic)

    1M NaOH : 10 mg/mL (11.37 mM; ultrasonic and adjust pH to 8 with NaOH)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1375 mL 5.6873 mL 11.3746 mL
    5 mM 0.2275 mL 1.1375 mL 2.2749 mL
    10 mM 0.1137 mL 0.5687 mL 1.1375 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 4.17 mg/mL (4.74 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 4.17 mg/mL (4.74 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥98.0%

    References
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    Product Name:
    MnTBAP chloride
    Cat. No.:
    HY-126397
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