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  3. MnTBAP chloride

MnTBAP chloride 

Cat. No.: HY-126397
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MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

For research use only. We do not sell to patients.

MnTBAP chloride Chemical Structure

MnTBAP chloride Chemical Structure

CAS No. : 55266-18-7

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Description

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].

IC50 & Target[1][2]

NFκB

 

In Vitro

MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].

In Vivo

MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].

Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
Dosage: 10 mg/kg
Administration: IP; three times per week for twelve weeks
Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
Molecular Weight

879.15

Formula

C₄₈H₂₈ClMnN₄O₈

CAS No.

55266-18-7

SMILES

[Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12

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Keywords:

MnTBAPNF-κBNuclear factor-κBNuclear factor-kappaBsuperoxidedismutaseSODscavengeranti-oxidativeBMPR-IINFκBfibroticresponsechronickidneyCKDsInhibitorinhibitorinhibit

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MnTBAP chloride
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