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MnTBAP chloride 

Cat. No.: HY-126397 Purity: ≥95.0%
Handling Instructions

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

For research use only. We do not sell to patients.

MnTBAP chloride Chemical Structure

MnTBAP chloride Chemical Structure

CAS No. : 55266-18-7

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25 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].

IC50 & Target[1][2]

NFκB

 

In Vitro

MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
Dosage: 10 mg/kg
Administration: IP; three times per week for twelve weeks
Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
Molecular Weight

879.15

Formula

C₄₈H₂₈ClMnN₄O₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (113.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1375 mL 5.6873 mL 11.3746 mL
5 mM 0.2275 mL 1.1375 mL 2.2749 mL
10 mM 0.1137 mL 0.5687 mL 1.1375 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥95.0%

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MnTBAP chloride
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HY-126397
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