1. Apoptosis
  2. RIP kinase
  3. GSK2983559

GSK2983559 

Cat. No.: HY-112038A Purity: 99.24%
Handling Instructions

GSK2983559 (compound 3) is a potent, specific and oral active receptor interacting protein 2 (RIP2) kinase inhibitor, which has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

For research use only. We do not sell to patients.

GSK2983559 Chemical Structure

GSK2983559 Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GSK2983559:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GSK2983559 (compound 3) is a potent, specific and oral active receptor interacting protein 2 (RIP2) kinase inhibitor, which has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

IC50 & Target[1]

RIPK2

 

In Vitro

Cell Viability Assay[2]

Cell Line: THP-1 cells
Concentration: 1-1024 nM
Incubation Time: 2 hours
Result: Inhibited IL-8 production with an IC50 of 1.34 nM.
In Vivo
Animal Model: C57BL/6 mice (female) injected with MDP (100 μg)[2]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage; 3 and 10 mg/kg; once
Result: Suppressed serum IL-6 levels in a dose-dependent manner.
Clinical Trial
Molecular Weight

611.61

Formula

C21H28CaN4O10PS2

SMILES

CC(C)(C)S(C(C(OCCOP(O)([O-])=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O.[H]O[H].[H]O[H].[H]O[H].[Ca+2].[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (3.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)

DMF : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

*GSK2983559 is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6350 mL 8.1751 mL 16.3503 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GSK2983559
Cat. No.:
HY-112038A
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