2. Apoptosis
  3. RIP kinase
  4. GSK2983559

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

For research use only. We do not sell to patients.

GSK2983559 Chemical Structure

GSK2983559 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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GSK2983559 Related Antibodies

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Description

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

IC50 & Target[1]

RIPK2

 

In Vitro

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK2983559 Related Antibodies

Cell Viability Assay[2]

Cell Line: THP-1 cells
Concentration: 1-1024 nM
Incubation Time: 2 hours
Result: Inhibited IL-8 production with an IC50 of 1.34 nM.
In Vivo

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (female) injected with MDP (100 μg)[2]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage; 3 and 10 mg/kg; once
Result: Suppressed serum IL-6 levels in a dose-dependent manner.
Clinical Trial
Molecular Weight

611.61

Formula

C21H28CaN4O10PS2+
Appearance

Solid

Color

Yellow to brown

SMILES

CC(C)(C)S(C(C(OCCOP(O)([O-])=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O.[H]O[H].[H]O[H].[H]O[H].[Ca+2].[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

DMF : < 1 mg/mL (insoluble)

Ethanol : < 1 mg/mL (insoluble)

*GSK2983559 is usually formulated as a suspension.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
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GSK2983559 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK2983559GSK 2983559GSK-2983559RIP kinaseReceptor-interacting protein kinasesRIPKTHP-1 cellInhibitorinhibitorinhibit

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HY-112038A
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