1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Tiludronate disodium

Tiludronate disodium (Synonyms: Tiludronic Acid disodium)

Cat. No.: HY-A0213A
Handling Instructions

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.

For research use only. We do not sell to patients.

Tiludronate disodium Chemical Structure

Tiludronate disodium Chemical Structure

CAS No. : 149845-07-8

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1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

In Vitro

The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

362.57

Formula

C₇H₇ClNa₂O₆P₂S

CAS No.
SMILES

O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 41.67 mg/mL (114.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7581 mL 13.7904 mL 27.5809 mL
5 mM 0.5516 mL 2.7581 mL 5.5162 mL
10 mM 0.2758 mL 1.3790 mL 2.7581 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Tiludronate disodiumTiludronic Acid disodiumProton PumporalbisphosphonateinflammatoryV-ATPaseosteoporosisyeastInhibitorinhibitorinhibit

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Tiludronate disodium
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