149845-07-8
149845-07-8
Chemical Structure
Tiludronate disodium
Synonym(s): Tiludronic acid disodium
- CAS No.: 149845-07-8
- Formula:C7H7ClNa2O6P2S
- Molecular Weight:362.57
IUPAC Name: sodium (((4-chlorophenyl)thio)methylene)bis(hydrogen phosphonate)
InChIKey: SKUHWSDHMJMHIW-UHFFFAOYSA-L
SMILES: O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1
Biological Activity: Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].
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Tiludronate disodium | 99.97% | Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties. | ||||||||||||||||||||
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Tiludronate-d5 sodium | Tiludronate-d5 (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties. | |||||||||||||||||||||
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References
- [1]. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2(8678-8679):1469-71. [Content Brief]
- [2]. Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018 Jan;89(1):105-116. [Content Brief]
- [3]. Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S. [Content Brief]
- [4]. David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996;11(10):1498-1507. [Content Brief]
