SRTCX1003

Cat. No.: HY-124240: FAQs
Data Sheet Handling Instructions

Molarity Calculator

SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses.

For research use only. We do not sell to patients.

SRTCX1003 Chemical Structure

CAS No. : 1203480-86-7

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Sirtuin Isoform Specific Products:

View All Isoforms

Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

Biological Activity
Purity & Documentation
References
Customer Review

Description

SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses^[1].

IC₅₀ & Target

SIRT1^[1]

In Vitro

SRTCX1003 (0-10 μM; 24 h) mediates a dose-dependent reduction of acetylated p65 protein in U2OS cells^[1].
SRTCX1003 (5 μM; 6 h) attenuates TNFα-induced p65 acetylation in HEK 293T/17 cells^[1].
SRTCX1003 (0-100 μM; 2 h) shows dose-dependent reduction of LPS (HY-D1056)-induced TNFα secretion from RAW cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot AnalysisHEK 293T/17

Cell Line:	HEK 293T/17
Concentration:	5 μM
Incubation Time:	6 h followed by 20 minutes TNFα stimulation
Result:	Significantly reduced TNFα-stimulated p65 acetylation.

In Vivo

SRTCX1003 (3-100 mg/kg; oral; once) decreases LPS (HY-D1056)-stimulated TNFα and IL-12p40 production in mice inflammation model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice, LPS-induced inflammation mouse model^[1]
Dosage:	3, 10, 30 and 100 mg/kg
Administration:	Oral, 60 minutes prior to LPS administration
Result:	Dose-dependently reduced LPS-stimulated TNFα and IL-12p40 production.

Molecular Weight

449.53

Formula

C₂₃H₂₃N₅O₃S

CAS No.

1203480-86-7

SMILES

O=C(NC1=NC=CS1)C2=C3N=C(NC3=CC=C2)C4=CC=CC=C4OCCN5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang H, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. [Content Brief]

SRTCX1003 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRTCX10031203480-86-7SRTCX 1003SRTCX-1003Sirtuinorally activep65TNFαHEK 293T/17RAW cellIL-12p40Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks