Delphinidin-3-sambubioside chloride
Based on 1 publication(s) in Google Scholar
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
For research use only. We do not sell to patients.
- Purity: 97.11%
- CAS No.: 53158-73-9
- Formula: C26H29ClO16
- Molecular Weight:632.95
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Delphinidin-3-sambubioside chloride
More
Biological Activity
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM[2].
Delphinidin-3-sambubioside chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW264.7 cells
-
Concentration:50, 100, 200 μM
-
Incubation Time:30 min
-
Result:Suppressed the degradation of IκB, and the phosphorylation of p65.
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:LPS-induced mouse paw edema model[1]
-
Dosage:15 μmol/kg
-
Administration:Intraperitoneal injection (i.p.), for 4 days.
-
Result:Reduced the LPS-induced paw thickness.
Decreased the edema by 89.3%.
Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
-
Animal Model:HFD-fed rats[3]
-
Dosage:30 mg/kg
-
Administration:Oral gavage, daily for eight weeks.
-
Result:Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
Chemical Information
-
CAS No. 53158-73-9
-
Appearance Solid
-
Molecular Weight 632.95
-
Formula C26H29ClO16
-
Color Brown to black
-
SMILES
O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)[C@H](OC3=C(C4=CC(O)=C(O)C(O)=C4)[O+]=C(C=C(O)C=C5O)C5=C3)O[C@H](CO)[C@H]1O.[Cl-]
-
Synonyms
Dp3‐Sam chloride
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int J Mol Sci
Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds. [Abstract]2025 Mar 2;26(5):2243. PMID: 40076865
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (454 KB)
- English - EN (454 KB)
- Français - FR (454 KB)
- Deutsch - DE (454 KB)
- Norwegian - NO (454 KB)
- Español - ES (454 KB)
- Swedish - SV (454 KB)
- Italian - IT (454 KB)
- Korean - KR (454 KB)
- Portuguese - PT (454 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sogo T, et al. Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a Hibiscus anthocyanin. Biofactors. 2015 Jan-Feb;41(1):58-65. [Content Brief]
[2]. Hou DX, et al. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005 Aug 1;440(1):101-9. [Content Brief]
[3]. Long Q, et al. Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells. Bioengineered. 2021 Dec;12(1):3837-3849. https://pubmed.ncbi.nlm.nih.gov/34281481/ [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Delphinidin-3-sambubioside chloride Related Classifications
HY-129143 Related Classifications
Powered by Bioz