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  5. Hibiscus sabdariffa Linn.
  6. Delphinidin-3-sambubioside chloride

Delphinidin-3-sambubioside chloride  (Synonyms: Dp3‐Sam chloride)

Cat. No.: HY-129143
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Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..

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Delphinidin-3-sambubioside chloride Chemical Structure

Delphinidin-3-sambubioside chloride Chemical Structure

CAS No. : 53158-73-9

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Delphinidin-3-sambubioside chloride Related Antibodies

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Description

Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L.[1][3].

In Vitro

Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM[2].
Delphinidin-3-sambubioside chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Delphinidin-3-sambubioside chloride Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 50, 100, 200 μM
Incubation Time: 30 min
Result: Suppressed the degradation of IκB, and the phosphorylation of p65.
In Vivo

Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累[3]。
Dosage: 15 μmol/kg
Administration: Intraperitoneal injection (i.p.), for 4 days.
Result: Reduced the LPS-induced paw thickness.
Decreased the edema by 89.3%.
Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
Animal Model: HFD-fed rats[3]
Dosage: 30 mg/kg
Administration: Oral gavage, daily for eight weeks.
Result: Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
Molecular Weight

632.95

Formula

C26H29ClO16
CAS No.
SMILES

O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)[C@H](OC3=C(C4=CC(O)=C(O)C(O)=C4)[O+]=C(C=C(O)C=C5O)C5=C3)O[C@H](CO)[C@H]1O.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delphinidin-3-sambubioside53158-73-9Dp3‐SamOthersAnthocyaninRAW264.7paw edemaLPSHepG2HFD ratlipid accumulationInhibitorinhibitorinhibit

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