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  3. Delphinidin 3-glucoside chloride

Delphinidin 3-glucoside chloride  (Synonyms: Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride)

Cat. No.: HY-108052 Purity: 99.67%
COA Handling Instructions

Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.

For research use only. We do not sell to patients.

Delphinidin 3-glucoside chloride Chemical Structure

Delphinidin 3-glucoside chloride Chemical Structure

CAS No. : 6906-38-3

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5 mg USD 310 In-stock
10 mg USD 510 In-stock
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Description

Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL)[1]. Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM[2]. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM[3]. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction[4][5][6].

IC50 & Target

IC50: 2.37 µM (EGFR)[3]

In Vitro

Delphinidin 3-glucoside chloride (30-100 μM) induces cell apoptosis in B CLL cells through redox-sensitive caspase 3 activation[1].
Delphinidin 3-glucoside chloride (0-40 μM) exhibits inhibitory activity towards breast cancer cells and carcinogen-induced breast carcinogenesis, through downregulation of the HOTAIR expression via pAKT/IRF1 signaling pathway[4].
Delphinidin 3-glucoside chloride (1-100 μM) inihibits the oxLDL-induced endothelial dysfunction in HUVECs with dependence of Sodium-Dependent Glucose Transporter (SGLT1)[5].
Delphinidin 3-glucoside chloride (0-50 μM) inhibits ADP, collagen or TRAP stimulated platelet aggregation through inhibition of AMPK phosphorylation[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: B CLLs
Concentration: 30-100 μM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Western Blot Analysis[4]

Cell Line: MDA-MB-231 and MCF-7, HUVECs, B CLLs
Concentration: 40 μM for MDA-MB-231 and MCF-7, 0-100 μM for HUVECS
Incubation Time: 24 h
Result: Inhibited AKT phosphorylation.
Increased levels of pro-apoptotic factors: Cyt c, caspase 3 and Bax, decreased levels of Bcl-2.

Immunofluorescence[4]

Cell Line: MDA-MB-231
Concentration: 0-40 μM
Incubation Time: 24 h
Result: Promoted IRF1 expression.
In Vivo

Delphinidin 3-glucoside chloride (40 mg/kg/day, i.g. for 25 days) inhibits tumor growth in MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice [4]. Delphinidin 3-glucoside chloride (50 μM, i.v.) inhibits thrombus growth in FeCl3 induced mesenteric arteriole injury in C57BL/6 mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice[4]
Dosage: 40 mg/kg/day
Administration: i.g., for 25 days
Result: Inhibited tumor growth.
Molecular Weight

500.84

Formula

C21H21ClO12

CAS No.
Appearance

Solid

Color

Purple to black

SMILES

OC1=CC(O)=CC2=C1C=C(C(C3=CC(O)=C(C(O)=C3)O)=[O+]2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO.[Cl-]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (19.97 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9966 mL 9.9832 mL 19.9665 mL
5 mM 0.3993 mL 1.9966 mL 3.9933 mL
10 mM 0.1997 mL 0.9983 mL 1.9966 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.5 mg/mL (1.00 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.83%

References
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Delphinidin 3-glucoside chloride Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Delphinidin 3-glucoside chloride
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HY-108052
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