2. Anti-infection Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Influenza Virus Angiotensin-converting Enzyme (ACE) Akt MMP
  4. Cyanidin 3-sambubioside chloride

Cyanidin 3-sambubioside chloride  (Synonyms: Cyanidin-3-O-sambubioside chloride)

Cat. No.: HY-N2533 Purity: 98.40%
COA
SDS
Handling Instructions Technical Support

Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties.

For research use only. We do not sell to patients.

Cyanidin 3-sambubioside chloride

Cyanidin 3-sambubioside chloride Chemical Structure

CAS No. : 33012-73-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyanidin 3-sambubioside chloride:

Cyanidin 3-sambubioside chloride Related Antibodies

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties[1][2][3].

In Vitro

Cyanidin 3-sambubioside chloride (5-25 μg/mL, 24 h) exhibits DPPH radical scavenging activity, antioxidative potency and reducing power[1].
Cyanidin 3-sambubioside chloride (50-400 μM, 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 cell[1].
Cyanidin 3-sambubioside chloride (1-30 µg/mL, 24 h) inhibits the angiogenesis in chick chorioallantoic membrane (CAM), inhibits the tube formation HUVEC cell, suppresses the migration and invasion of MDA-MB-231 through inhibition of Akt phosphorylation and MMP-9[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyanidin 3-sambubioside chloride Related Antibodies

Western Blot Analysis[2]

Cell Line: MDA-MB-231
Concentration: 1-30 µg/mL
Incubation Time: 24 h
Result: Inhibited the expression of MMP-9, MMP-2 and p-Akt.

Cell Invasion Assay[2]

Cell Line: MDA-MB-231
Concentration: 1-30 µg/mL
Incubation Time: 24 h
Result: Inhibited the cell invasion.
Molecular Weight

616.95

Formula

C26H29ClO15
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

OC1=CC(O)=CC2=C1C=C(C(C3=CC(O)=C(C=C3)O)=[O+]2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O[C@H]5[C@@H]([C@H]([C@@H](CO5)O)O)O.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (81.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6209 mL 8.1044 mL 16.2088 mL
5 mM 0.3242 mL 1.6209 mL 3.2418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.40%

SDS (252 KB)

COA (258 KB) HNMR (165 KB) CNMR (175 KB) RP-HPLC (147 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6209 mL 8.1044 mL 16.2088 mL 40.5219 mL
5 mM 0.3242 mL 1.6209 mL 3.2418 mL 8.1044 mL
10 mM 0.1621 mL 0.8104 mL 1.6209 mL 4.0522 mL
15 mM 0.1081 mL 0.5403 mL 1.0806 mL 2.7015 mL
20 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0261 mL
25 mM 0.0648 mL 0.3242 mL 0.6484 mL 1.6209 mL
30 mM 0.0540 mL 0.2701 mL 0.5403 mL 1.3507 mL
40 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0130 mL
50 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8104 mL
60 mM 0.0270 mL 0.1351 mL 0.2701 mL 0.6754 mL
80 mM 0.0203 mL 0.1013 mL 0.2026 mL 0.5065 mL
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Cyanidin 3-sambubioside chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyanidin 3-sambubioside33012-73-6Cyanidin-3-O-sambubiosideInfluenza VirusAngiotensin-converting Enzyme (ACE)AktMMPPKBProtein kinase BMatrix metalloproteinasesanthocyaninMMP-9anti-angiogenicantioxidantneuraminidaseantiviralInhibitorinhibitorinhibit

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