Cat. No.: HY-105935

Keracyanin chloride

(Synonyms: Cyanidin 3-rutinoside chloride; Cyanidin 3-O-rutinoside chloride; Sambucin chloride)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active.

For research use only. We do not sell to patients.

Purity: 99.90%
CAS No.: 18719-76-1
Formula: C₂₇H₃₁ClO₁₅
Molecular Weight:630.98

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Keracyanin chloride Chemical Structure

CAS No.: 18719-76-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active^[1]^[2]^[3]^[4]^[5].

All NF-κB Isoforms :

All PPAR Isoforms :

All p38 MAPK Isoforms :

All ERK Isoforms :

All JNK Isoforms :

In Vitro

Keracyanin chloride (0.8 μM, 48 h) suppresses the phosphorylation level of NF-κB p65, inhibits the protein expression of PPAR-γ in THP-1 cell, downregulates the inflammation-related gene expression of TNF-α, IL-1β, IL-6 and MCP-1^[3].
Keracyanin chloride (10-200 µM, 24 h) inhibits blue light-induced ROS generation in HaCaT cell, inhibits FAK/MAPK/ERK/JNK signaling pathway, thereby exhibiting anti-inflammatory effect^[4].
Keracyanin chloride exhibits a weak inhibitory activity against intestinal α-glucosidase (IC₅₀s for maltase and sucrase are 2323 μM and 250.2 μM), delays carbohydrate digestion and absorption, and exhibits hypoglycemic effect^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

THP-1
Concentration:

0.8 μM
Incubation Time:

48 h
Result:

Inhibited the PPAR-γ expression and phosphorylation of NF-κB p65.

Real Time qPCR^[3]

Cell Line:

THP-1
Concentration:

0.8 μM
Incubation Time:

48 h
Result:

Downregulated the mRNA expression levels of TNF-α, IL-1β, IL-6 and MCP-1.

In Vivo

Keracyanin chloride (30-300 mg/kg, po, single dose) reduces postprandial blood glucose levels in Wistar rats models^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats models^[5]
Dosage:

30-300 mg/kg
Administration:

po, single dose
Result:

Inhibited the increase in blood glucose after oral administration of maltose and sucrose.

Chemical Information

CAS No. 18719-76-1
Appearance Solid
Molecular Weight 630.98
Formula C₂₇H₃₁ClO₁₅
Color Brown to reddish brown
SMILES

OC1=C2C([O+]=C(C3=CC(O)=C(O)C=C3)C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O)=C2)=CC(O)=C1.[Cl-]
Synonyms

Cyanidin 3-rutinoside chloride; Cyanidin 3-O-rutinoside chloride; Sambucin chloride
Structure Classification
- Flavonoids
- Anthocyans
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (39.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5848 mL

7.9242 mL

15.8484 mL

5 mM

0.3170 mL

1.5848 mL

3.1697 mL

10 mM

0.1585 mL

0.7924 mL

1.5848 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mazzaracchio P, et al. Interaction between gliadins and anthocyan derivatives. Food Chem. 2011 Dec 1;129(3):1100-7. [Content Brief]

[2]. Matsufuji H, et al. Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. J Agric Food Chem. 2004 Sep 8;52(18):5759-63. [Content Brief]

[3]. Santamarina AB , et al., Anti-inflammatory effects of oleic acid and the anthocyanin keracyanin alone and in combination: effects on monocyte and macrophage responses and the NF-κB pathway. Food Funct. 2021 Sep 7;12(17):7909-7922. [Content Brief]

[4]. Lee H Y, et al. Cherry fruit anthocyanins cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside protect against blue light-induced cytotoxicity in HaCaT cells[J]. Applied Biological Chemistry, 2023, 66(1): 3.

[5]. Adisakwattana S, et al., Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. J Clin Biochem Nutr. 2011 Jul;49(1):36-41. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5848 mL	7.9242 mL	15.8484 mL	39.6209 mL
	5 mM	0.3170 mL	1.5848 mL	3.1697 mL	7.9242 mL
	10 mM	0.1585 mL	0.7924 mL	1.5848 mL	3.9621 mL
	15 mM	0.1057 mL	0.5283 mL	1.0566 mL	2.6414 mL
	20 mM	0.0792 mL	0.3962 mL	0.7924 mL	1.9810 mL
	25 mM	0.0634 mL	0.3170 mL	0.6339 mL	1.5848 mL
	30 mM	0.0528 mL	0.2641 mL	0.5283 mL	1.3207 mL

Keywords

Keracyanin chloride

1 Cited Publications

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Keracyanin chloride

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Publications Citing Use of MedChemExpress (MCE) Keracyanin chloride

All NF-κB Isoforms

All PPAR Isoforms

All p38 MAPK Isoforms

All ERK Isoforms

All JNK Isoforms

Biological Activity

Chemical Information