1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    MMP
  3. Glucocorticoid receptor-IN-2

Glucocorticoid receptor-IN-2 

Cat. No.: HY-142942
Handling Instructions

Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV.

For research use only. We do not sell to patients.

Glucocorticoid receptor-IN-2 Chemical Structure

Glucocorticoid receptor-IN-2 Chemical Structure

CAS No. : 2664932-65-2

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Description

Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].

In Vitro

Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1].
Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.46

Formula

C25H20F4N6O2

CAS No.
SMILES

CC(F)(F)C(N[[email protected]@H](C)[[email protected]@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=C5)C5=C2)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Glucocorticoid receptor-IN-2
Cat. No.:
HY-142942
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