2664932-65-2
Chemical Structure
Glucocorticoid receptor-IN-2
- CAS No.: 2664932-65-2
- Formula:C25H20F4N6O2
- Molecular Weight:512.46
IUPAC Name: N-((1R,2S)-1-((1-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-1H-indazol-5-yl)oxy)-1-(3,5-difluorophenyl)propan-2-yl)-2,2-difluoropropanamide
InChIKey: ADSMVTGYTNOHRQ-PSLXWICFSA-N
SMILES: CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=C5)C5=C2)=O
Biological Activity: Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].
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Glucocorticoid receptor-IN-2 | Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV. | |||||||||||||||||||||
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Keywords
