1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Rosiptor

Rosiptor (Synonyms: AQX-1125)

Cat. No.: HY-109011 Purity: >98.0%
Handling Instructions

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

For research use only. We do not sell to patients.

Rosiptor Chemical Structure

Rosiptor Chemical Structure

CAS No. : 782487-28-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 770 In-stock
Estimated Time of Arrival: December 31
5 mg USD 700 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 5500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].

IC50 & Target

SHIP1[1]

In Vitro

Rosiptor (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation)
Concentration: 0.1, 1, 10 μM
Incubation Time: 30 minutes
Result: Induced a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it failed to affect Akt phosphorylation in Jurkat cells.
In Vivo

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks old male CD-1 mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: p.o.; daily for 3 days
Result: Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.
Animal Model: Male Sprague-Dawley rats[1]
Dosage: 10 mg/kg (Pharmacokinetic Study)
Administration: Oral administration
Result: The Cmax value is 0.830 μM and the t1/2 value is 5.2 hours.
Clinical Trial
Molecular Weight

321.50

Formula

C₂₀H₃₅NO₂

CAS No.

782487-28-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (466.56 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1104 mL 15.5521 mL 31.1042 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL
10 mM 0.3110 mL 1.5552 mL 3.1104 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

RosiptorAQX-1125AQX1125AQX 1125PhosphataseInhibitorinhibitorinhibit

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Rosiptor
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HY-109011
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