2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Rosiptor

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

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Rosiptor Chemical Structure

Rosiptor Chemical Structure

CAS No. : 782487-28-9

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 490 In-stock
25 mg USD 784 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Rosiptor:

Rosiptor Related Antibodies

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  • Purity & Documentation

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Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].

IC50 & Target

SHIP1[1]
In Vitro

Rosiptor (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rosiptor Related Antibodies

Western Blot Analysis[1]

Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation)
Concentration: 0.1, 1, 10 μM
Incubation Time: 30 minutes
Result: Induced a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it failed to affect Akt phosphorylation in Jurkat cells.
In Vivo

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks old male CD-1 mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: p.o.; daily for 3 days
Result: Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.
Animal Model: Male Sprague-Dawley rats[1]
Dosage: 10 mg/kg (Pharmacokinetic Study)
Administration: Oral administration
Result: The Cmax value is 0.830 μM and the t1/2 value is 5.2 hours.
Clinical Trial
Molecular Weight

321.50

Formula

C20H35NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@H]1CO)(CC[C@H](O)C1)[C@](CC[C@@]2(C)[C@@]3([H])CCC2=C)([H])[C@H]3CN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (466.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1104 mL 15.5521 mL 31.1042 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.35%

COA (249 KB) HNMR (249 KB) RP-HPLC (147 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1104 mL 15.5521 mL 31.1042 mL 77.7605 mL
5 mM 0.6221 mL 3.1104 mL 6.2208 mL 15.5521 mL
10 mM 0.3110 mL 1.5552 mL 3.1104 mL 7.7760 mL
15 mM 0.2074 mL 1.0368 mL 2.0736 mL 5.1840 mL
20 mM 0.1555 mL 0.7776 mL 1.5552 mL 3.8880 mL
25 mM 0.1244 mL 0.6221 mL 1.2442 mL 3.1104 mL
30 mM 0.1037 mL 0.5184 mL 1.0368 mL 2.5920 mL
40 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.9440 mL
50 mM 0.0622 mL 0.3110 mL 0.6221 mL 1.5552 mL
60 mM 0.0518 mL 0.2592 mL 0.5184 mL 1.2960 mL
80 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9720 mL
100 mM 0.0311 mL 0.1555 mL 0.3110 mL 0.7776 mL
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Rosiptor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosiptor782487-28-9AQX-1125AQX1125AQX 1125PhosphataseInhibitorinhibitorinhibit

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