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  2. Bacterial
  3. Skullcapflavone II

Skullcapflavone II 

Cat. No.: HY-N6624
Handling Instructions

Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.

For research use only. We do not sell to patients.

Skullcapflavone II Chemical Structure

Skullcapflavone II Chemical Structure

CAS No. : 55084-08-7

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Description

Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].

In Vitro

Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency[2].

In Vivo

Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways[3].

Molecular Weight

374.34

Formula

C₁₉H₁₈O₈

CAS No.

55084-08-7

SMILES

COC1=C2C(C(C=C(C3=C(C=CC=C3O)OC)O2)=O)=C(O)C(OC)=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Skullcapflavone IIBacterialantimicrobialosteoclastdifferentiationinflammatorymycobacterialflavonoidInhibitorinhibitorinhibit

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