Polaprezinc
Based on 1 publication(s) in Google Scholar
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 107667-60-7
- Formula: C9H11N4O3Zn
- Molecular Weight:288.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Polaprezinc
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Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 107667-60-7
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Appearance Solid
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Molecular Weight 288.59
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Formula C9H11N4O3Zn
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Color White to off-white
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SMILES
O=C1[C@@H]([N-](C2=O)[Zn+2](NCC2)[O-]1)CC3=CN=CN3
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Synonyms
Zinc L-carnosine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer. [Abstract]2024 Mar;11(9):e2304939. PMID: 38115765
Solvent & Solubility
In Vitro:
1 M HCl : 50 mg/mL (173.26 mM; Need ultrasonic)
H2O : 1 mg/mL (3.47 mM; ultrasonic and adjust pH to 2 with HCl)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1 M HCl | 1 mM | 3.4651 mL | 17.3256 mL | 34.6512 mL | 86.6281 mL |
| 1 M HCl | 5 mM | 0.6930 mL | 3.4651 mL | 6.9302 mL | 17.3256 mL |
| 10 mM | 0.3465 mL | 1.7326 mL | 3.4651 mL | 8.6628 mL | |
| 15 mM | 0.2310 mL | 1.1550 mL | 2.3101 mL | 5.7752 mL | |
| 20 mM | 0.1733 mL | 0.8663 mL | 1.7326 mL | 4.3314 mL | |
| 25 mM | 0.1386 mL | 0.6930 mL | 1.3860 mL | 3.4651 mL | |
| 30 mM | 0.1155 mL | 0.5775 mL | 1.1550 mL | 2.8876 mL | |
| 40 mM | 0.0866 mL | 0.4331 mL | 0.8663 mL | 2.1657 mL | |
| 50 mM | 0.0693 mL | 0.3465 mL | 0.6930 mL | 1.7326 mL | |
| 60 mM | 0.0578 mL | 0.2888 mL | 0.5775 mL | 1.4438 mL | |
| 80 mM | 0.0433 mL | 0.2166 mL | 0.4331 mL | 1.0829 mL | |
| 100 mM | 0.0347 mL | 0.1733 mL | 0.3465 mL | 0.8663 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Polaprezinc Related Classifications
HY-B0729 Related Classifications
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