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NS-398

21 Cited Publications
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Based on 21 publication(s) in Google Scholar

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.

For research use only. We do not sell to patients.

  • Purity: 99.71%
  • CAS No.: 123653-11-2
  • Formula: C13H18N2O5S
  • Molecular Weight:314.36
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • NS-398 Chemical Structure
    NS-398 Chemical Structure
  • Experimental Validation Results for NS-398
  • Experimental Validation Results for NS-398
  • Experimental Validation Results for NS-398
CAS No.: 123653-11-2
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  • NS-398 Chemical Structure
    NS-398 Chemical Structure
    1/16
  • 1/16

    NS-398 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

    Customer Validation
     Expression of E-cadherin and vimentin is regulated by COX‑2. MG‑63 cells are infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (A) The expression of E-cadherin (green) in each group was determined using immunofluorescence. (B) Quantification of E‑cadherin expression.

  • 1/16

    NS-398 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

    Customer Validation
     Expression of E-cadherin and vimentin is regulated by COX‑2. MG‑63 cells are infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (C) The expression of vimentin in each group. (D) Quantification of vimentin expression.

  • 1/16

    NS-398 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

    Customer Validation
     Expression of NF‑κB p65 protein is regulated by COX‑2. MG‑63 cells were infected with control or COX‑2‑overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (A)The expression of NF-κB p65 (green) in each group was determined by immunofluorescence. (B) Quantification of NF-κB p65 expression.

  • NS-398