Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):332-6. doi: 10.1016/j.bmcl.2006.10.065.
Min Wang  1 ,  Gabrielle Lacy ,  Mingzhang Gao ,  Kathy D Miller ,  George W Sledge ,  Qi-Huang Zheng
Affiliations
  • 1. Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
PMID: 17095221 DOI: 10.1016/j.bmcl.2006.10.065
Abstract

Aromatase is a particularly good target in the treatment of Estrogen receptor positive breast Cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([11C]3a-f, alkyl=propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast Cancer.