2. Anti-infection
  3. Bacterial
  4. Antimicrobial agent-6

Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity.

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Antimicrobial agent-6 Chemical Structure

Antimicrobial agent-6 Chemical Structure

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Antimicrobial agent-6 Related Antibodies

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Description

Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity[1].

In Vitro

Antimicrobial agent-6 (Compound 11) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 5 μg/mL[1].
Antimicrobial agent-6 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 102.4[1].
Antimicrobial agent-6 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells[1].
Antimicrobial agent-6 is resistant to various physiological salts, human serum, and proteases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimicrobial agent-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration: 0-256 μg/mL
Incubation Time: 18-24 h
Result: Inhibited bacterial growth with MICs of 8, 4, 4 and 4 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.

RT-PCR[1]

Cell Line: LPS-stimulated RAW 264.7 macrophages
Concentration: 5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
Incubation Time: 18 h
Result: Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.
Molecular Weight

769.04

Formula

C40H64N16
SMILES

NCCCCNC1=NC(NCCCCN)=NC(N(C(CN2C3=NC(NCCCCN)=NC(NCCCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimicrobial agent-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimicrobial agent-6Antimicrobial agent6Antimicrobial agent 6Bacterialantimicrobialanti-inflammatoryE. coliP. aeruginosaS. epidermidisS. aureusInhibitorinhibitorinhibit

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