Momordicoside G
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury.
For research use only. We do not sell to patients.
- CAS No.: 81371-54-2
- Formula: C37H60O8
- Molecular Weight:632.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Raw264.7 macrophages is stimulated by 10 ng/mL LPS or 10 ng/mL IL-10 for 24 h to obtain M1-like (iNOS+) and M2-like (arginase+) macrophages[1].
Momordicoside G (10-40 μM; 24 h) inhibits the cell viability of M1 macrophages, but not M2 macrophage[1].
Momordicoside G (40 μM) induces M1 macrophage apoptosis in vitro, as well as decreasing the level of NO, and increasing the level of IL-12, IL-10, and TGF-β[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:M1 macrophages, M2 macrophages
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Concentration:10 μM, 20 μM, 40 μM
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Incubation Time:24 hours
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Result:Selectively decreased the cell viability of M1 macrophages, instead of M2 macrophages.
Momordicoside G (50 mg/kg; p.o.; once daily for 4 or 8 weeks) prevents urethane-induced lung injury and carcinoma lesions in mouse lung carcinogenic model[1].
Momordicoside G (50 mg/kg; p.o.; once daily for 2 weeks) promotes lung injury repair in LPS-induced lung injury model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse lung carcinogenic model: Urethane-induced lung carcinogenic model and LPS-induced lung injury model[1]
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Dosage:50 mg/kg
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Administration:Oral gavage; once daily for 4 or 8 weeks
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Result:Affected inflammasome and cytokines during urethane-induced lung injury and carcinoma lesions.
Exhibits macrophage-regulating capacity in LPS-induced lung injury model.
Chemical Information
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CAS No. 81371-54-2
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Molecular Weight 632.87
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Formula C37H60O8
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SMILES
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@H](C)C/C=C/C(C)(C)OC)([H])CC2)C)[C@@]5([H])[C@@](OC4)(C(C)([C@@H](O[C@]6([H])O[C@@H]([C@@H](O)[C@@H](O)[C@H]6O)CO)CC5)C)C=C3
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Synonyms
Momordicacoside G
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Momordicoside G Related Classifications
HY-N3248 Related Classifications
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