1. Terpenoids and Glycosides
  2. Bakkenolide B

Bakkenolide B 

Cat. No.: HY-N7292
Handling Instructions

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma.

For research use only. We do not sell to patients.

Bakkenolide B Chemical Structure

Bakkenolide B Chemical Structure

CAS No. : 18455-98-6

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Description

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].

In Vitro

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].

Western Blot Analysis[1]

Cell Line: Mouse peritoneal macrophages
Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time: 1 h later stimulated with LPS
Result: Decreased iNOS and cox-2 protein expression.
In Vivo

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].

Animal Model: Ovalbumin-induced asthma mice[1]
Dosage: 1 mg/ml
Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result: Exhibited anti-allergic effects in mice.
Molecular Weight

390.47

Formula

C₂₂H₃₀O₆

CAS No.

18455-98-6

SMILES

C/C=C(C)\C(O[[email protected]@H]1[[email protected]]2([H])[[email protected]@H](OC(C)=O)[[email protected]]3(C[[email protected]]2(C)[[email protected]@H](C)CC1)C(OCC3=C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Bakkenolide BOthersβ-hexosamidaseRBL-2H3mast cellasthmaOvalbumin-inducedantiallergicanti-inflammatoryanti-allergicBALFInhibitorinhibitorinhibit

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Bakkenolide B
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HY-N7292
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