Bakkenolide B
Based on 1 Customer Validation
Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma.
For research use only. We do not sell to patients.
- Purity: 96%
- CAS No.: 18455-98-6
- Formula: C22H30O6
- Molecular Weight:390.47
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse peritoneal macrophages
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Concentration:0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
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Incubation Time:1 h later stimulated with LPS
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Result:Decreased iNOS and cox-2 protein expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovalbumin-induced asthma mice[1]
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Dosage:1 mg/ml
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Administration:Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
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Result:Exhibited anti-allergic effects in mice.
Chemical Information
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CAS No. 18455-98-6
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Appearance Solid
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Molecular Weight 390.47
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Formula C22H30O6
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Color White to off-white
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SMILES
C/C=C(C)\C(O[C@@H]1[C@]2([H])[C@@H](OC(C)=O)[C@]3(C[C@]2(C)[C@@H](C)CC1)C(OCC3=C)=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee KP, et al. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.J Ethnopharmacol. 2013 Jul 30;148(3):890-4. [Content Brief]
[2]. Wang M, Zhang Q, Wang H, et al. Characterization and NO inhibitory activities of chemical constituents from an edible plant Petasites tatewakianus. J Agric Food Chem. 2014;62(38):9362-9367. [Content Brief]
[3]. Park SY, Choi MH, Park G, Choi YW. Petasites japonicus bakkenolide B inhibits lipopolysaccharide‑induced pro‑inflammatory cytokines via AMPK/Nrf2 induction in microglia. Int J Mol Med. 2018;41(3):1683-1692. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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