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  5. Bakkenolide B

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma.

For research use only. We do not sell to patients.

Bakkenolide B Chemical Structure

Bakkenolide B Chemical Structure

CAS No. : 18455-98-6

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Description

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].

In Vitro

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Mouse peritoneal macrophages
Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time: 1 h later stimulated with LPS
Result: Decreased iNOS and cox-2 protein expression.
In Vivo

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovalbumin-induced asthma mice[1]
Dosage: 1 mg/ml
Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result: Exhibited anti-allergic effects in mice.
Molecular Weight

390.47

Formula

C22H30O6

CAS No.
SMILES

C/C=C(C)\C(O[C@@H]1[C@]2([H])[C@@H](OC(C)=O)[C@]3(C[C@]2(C)[C@@H](C)CC1)C(OCC3=C)=O)=O

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Bakkenolide B
Cat. No.:
HY-N7292
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